Development of a dural substitute from synthetic bioabsorbable polymers

Journal of Neurosurgery
K YamadaK Yamamoto

Abstract

A new bioabsorbable composite sheet was developed to provide a substitute for the dura mater and was evaluated histologically and biomechanically using rats and rabbits. This composite, composed of two L-lactic acid-epsilon-caprolactone (50% L-lactic acid, 50% epsilon-caprolactone) copolymer films and a poly(glycolic acid) nonwoven fabric, displayed good mechanical properties and was completely absorbed 24 weeks after implantation in the back of rats. Histological evaluation of the composite sheet was undertaken by implanting it in 31 rabbits with dural defects and examining the sites of implantation 2 weeks to 26 months later. No infection, cerebrospinal fluid leakage, evidence of convulsive disorders, significant adhesion to underlying cortex, or calcification was noticed in any cases. In addition, the regenerated duralike tissue had a high pressure-resistant strength 2 weeks after implantation. The authors conclude that this new bioabsorbable composite sheet can be successfully used as a dural substitute.

References

Sep 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·M R Macfarlane, L Symon
Jan 1, 1992·Acta neurochirurgica·N MeddingsS D Gorham
Apr 1, 1991·Biomaterials·K Pietrucha
Feb 1, 1991·Journal of Biomedical Materials Research·R L CollinsF H Silver
Jun 1, 1990·Southern Medical Journal·K V ThammavaramL Kesterson
Jul 1, 1989·Journal of Neurosurgery·C E NussbaumJ V McDonald
Apr 1, 1989·Journal of Neurosurgery·A R CohenJ Ransohoff
Aug 1, 1987·Journal of Biomedical Materials Research·M AprahamianM Rabaud
Sep 1, 1985·Journal of Neurosurgery·P K Maurer, J V McDonald
May 1, 1984·Journal of Neurosurgery·C M OngkikoS B Dunsker
Aug 1, 1984·Journal of Neurosurgery·P O'Neill, A E Booth
Nov 1, 1995·Journal of Neurosurgery·S BhatiaE L Spatz
Jan 1, 1995·Acta neurochirurgica·G Gudmundsson, I Søgaard
Mar 1, 1995·Journal of Neurosurgery·P K NarotamK D Bhoola
Mar 1, 1993·Journal of Neurosurgery·A LaquerriereM Tadie
Mar 1, 1958·Journal of Neurosurgery·J B CAMPBELLJ W ROBERTSON

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Citations

Nov 14, 2000·Journal of Biomedical Materials Research·E ItohY Ikada
Feb 27, 2004·Surgical Neurology·Shafiqul IslamShigeharu Suzuki
Jan 7, 2004·Surgical Neurology·Emanuela CaroliRoberto Delfini
Jun 19, 2002·Biomaterials·D DufraneY J Schneider
Apr 23, 2003·Advanced Drug Delivery Reviews·Hiroki Ueda, Yasuhiko Tabata
Mar 9, 2000·Pharmaceutical Science & Technology Today·I Tabata
Sep 15, 2004·Tissue Engineering·Akishige HokugoYasuhiko Tabata
Jun 17, 2009·Tissue Engineering. Part a·Yoshitaka WadaWilliam J Landis
Jul 3, 2009·Journal of Neurosurgery. Spine·E Andrew StevensRobert G Ojemann
Feb 13, 2002·Journal of Neurosurgery·Eiji TachibanaJun Yoshida
May 7, 2002·Journal of Neurosurgery·Keisuke YamadaHaruhiko Kikuchi
Jun 21, 2003·Journal of Neurosurgery·Denis DufraneChristian Delloye
Jan 7, 2004·Journal of Neurosurgery·Cormac O MaherMichael J Link
Nov 30, 1999·Critical Reviews in Neurosurgery : CR·R BerjanoM Dujovny
Nov 29, 2011·World Neurosurgery·José Humberto Sandoval-SánchezGuadalupe Jorge-Espinoza
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Toshihiko SatoTatsuo Nakamura
Sep 30, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Elizabeth A Nunamaker, Daryl R Kipke
May 21, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yu-fei WangDa-jun Ying
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Stefan A MüllerVolker Schumpelick
Jun 29, 2004·Clinics in Plastic Surgery·Ralph E HolmesMiles Z Beckett
Sep 14, 2014·Interactive Cardiovascular and Thoracic Surgery·Masatsugu HamajiTatsuo Nakamura
Dec 3, 2014·Acta Biomaterialia·Toshiki MatsuiHiroo Iwata
Oct 26, 2005·The Annals of Thoracic Surgery·Kei SakumaKoichi Tabayashi
Jun 10, 2016·Journal of Materials Science. Materials in Medicine·Jintamai SuwanprateebWarinkarn Hemstapat
Feb 2, 2017·Journal of Materials Science. Materials in Medicine·Frederico de Melo Tavares de LimaJosé Lamartine de Andrade Aguiar
Aug 26, 2004·Congenital Anomalies·Yasuhiko Tabata
Apr 28, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vasilios A ZerrisCarl B Heilman
Apr 22, 2008·Artificial Organs·Tomokazu MukaiKazuo Takakuda
May 16, 2019·Journal of Korean Neurosurgical Society·Hasan Emre AydınAli Arslantas
Jun 13, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kelly E FlanaganDavid Kaplan

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