Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy

Journal of Nanobiotechnology
Prakhar SengarPierrick G J Fournier

Abstract

Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light. X-ray-mediated photodynamic therapy (PDT) has gained a major attention owing to the limitless penetration of X-rays. However, substantial outcomes have still not been achieved due to the low luminescence efficiency of scintillating nanoparticles and weak energy transfer to the photosensitizer. The present work describes the development of Y2.99Pr0.01Al5O12-based (YP) mesoporous silica coated nanoparticles, multifunctionalized with protoporphyrin IX (PpIX) and folic acid (YPMS@PpIX@FA) for potential application in targeted deep PDT. A YP nanophosphor core was synthesized using the sol-gel method to be used as X-ray energy transducer and was then covered with a mesoporous silica layer. The luminescence analysis indicated a good spectral overlap between the PpIX and nanoscintillator at the Soret as well as Q-band region. The comparison of the emission spectra with or without PpIX showed signs of energy transfer, a prerequisite for deep PDT. In vitro studies showed the preferential uptake of the nanocomposite in cancer cells expressing the folate receptorFolr1, validat...Continue Reading

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Citations

Aug 1, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Benjamin ClineJin Xie
May 21, 2019·Chemical Society Reviews·Xiaofeng ChenHuanghao Yang
Jan 2, 2021·Colloids and Surfaces. B, Biointerfaces·Ping TangLiyun Zhong
Apr 4, 2021·Acta Biomaterialia·Rui SangWei Deng
Jun 15, 2021·Photochemistry and Photobiology·Chloe B SmithAlvin A Holder
Jul 25, 2021·Cancers·José Francisco AlgorriJosé Miguel López-Higuera
Nov 7, 2020·ACS Applied Materials & Interfaces·Alexandra CantaranoGéraldine Dantelle

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Methods Mentioned

BETA
X-ray
Infrared Spectroscopy
light scattering
PCR
flow cytometry
transmission electron microscopy
dynamic light scattering
FRET
confocal microscopy

Software Mentioned

GraphPad Prism
GraphPad
Attune Cytometric
Gatan Microscopy Suite
Primer3Plus

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