Development of a health economic model to evaluate the potential benefits of optimal serum potassium management in patients with heart failure

Journal of Medical Economics
Ameet BakhaiMarc Evans

Abstract

Patients with heart failure are at increased risk of hyperkalemia, particularly when treated with renin-angiotensin-aldosterone system inhibitor (RAASi) agents. This study developed a model to quantify the potential health and economic value associated with sustained potassium management and optimal RAASi therapy in heart failure patients. A patient-level, fixed-time increment stochastic simulation model was designed to characterize the progression of heart failure through New York Heart Association functional classes, and predict associations between serum potassium levels, RAASi use, and consequent long-term outcomes. Following internal and external validation exercises, model analyses sought to quantify the health and economic benefits of optimizing both serum potassium levels and RAASi therapy in heart failure patients. Analyses were conducted using a UK payer perspective, independent of costs and utilities related to pharmacological potassium management. Validation against multiple datasets demonstrated the predictive capability of the model. Compared to those who discontinued RAASi to manage serum potassium, patients with normokalemia and ongoing RAASi therapy benefited from longer life expectancy (+1.38 years), per-patie...Continue Reading

References

Jan 5, 2002·The New England Journal of Medicine·J N CohnUNKNOWN Valsartan Heart Failure Trial Investigators
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Donald SilverbergAdrian Iaina
Aug 6, 2004·The New England Journal of Medicine·David N JuurlinkDonald A Redelmeier
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Jul 24, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Alexander GöhlerDavid J Cohen
Dec 2, 2009·Current Heart Failure Reports·Akshay S Desai
Dec 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anja Lehnhardt, Markus J Kemper
Mar 23, 2011·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Patrick W SullivanVahram Ghushchyan
Feb 22, 2012·The American Journal of Cardiology·Nishank JainSubhash Banerjee
Sep 20, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J Jaime CaroUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Oct 26, 2012·European Heart Journal·Stuart J PocockUNKNOWN Meta-Analysis Global Group in Chronic Heart Failure
Jun 7, 2014·Archives of Medical Science : AMS·Jagadish KhanagaviStephen Peterson
Nov 22, 2014·The New England Journal of Medicine·Matthew R WeirUNKNOWN OPAL-HK Investigators
Nov 22, 2014·The New England Journal of Medicine·David K PackhamBhupinder Singh
May 9, 2015·Journal of Cardiac Failure·James C FangUNKNOWN Heart Failure Society of America Guidelines Committee
Jul 15, 2015·JAMA : the Journal of the American Medical Association·George L BakrisUNKNOWN AMETHYST-DN Investigators
Sep 12, 2015·Perspectives in Public Health·W J Bryans
Oct 27, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Jiacong LuoAlex Yang
Feb 13, 2016·European Journal of Heart Failure·Tonje ThorvaldsenLars H Lund
Jul 16, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Maria Lukács KrogagerPeter Søgaard
Sep 28, 2016·Postgraduate Medical Journal·Christopher OrsborneSimon G Williams
Oct 12, 2017·European Heart Journal·Mette AldahlPeter Søgaard
Apr 1, 2016·Kidney International Supplements·Csaba P Kovesdy

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Citations

Dec 5, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angela Yee-Moon Wang

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