Development of a high sensitivity quantum dot-based fluorescent quenching lateral flow assay for the detection of zearalenone

Analytical and Bioanalytical Chemistry
Yuan ChenYong Tang

Abstract

Zearalenone (ZEN) is a common carcinogenic toxin related to cereal contamination. In this study, we developed a high sensitivity quantum dot (QD)-based fluorescent quenching lateral flow assay (LFA) for sensitive ZEN detection. The linear detection range of the fluorescent quenching LFA for ZEN was 0.78-25 ng/mL, and the limit of detection was 0.58 ng/mL. In addition, the fluorescent quenching LFA showed high recovery (83.1-93.6%) for detection of ZEN concentrations spiked into corn samples. These results indicate that the QD-based fluorescent quenching LFA may be a valuable tool for preliminary screening of ZEN contamination.

References

Oct 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abdellah ZinedineJordi Mañes
Feb 12, 2009·ACS Nano·Jianping XieDaniel I C Wang
Apr 8, 2009·Journal of Agricultural and Food Chemistry·Won-Bo ShimDuck-Hwa Chung
Jun 23, 2010·Journal of the American Chemical Society·Ying WangYuehe Lin
Mar 19, 2016·Biosensors & Bioelectronics·Huihua QuYan Zhao

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Citations

Sep 30, 2020·The Analyst·Shengyang ZhouChuanlai Xu
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Yogesh Kumar, Kairam Narsaiah
Oct 17, 2020·Analytical and Bioanalytical Chemistry·Jingming ZhouAiping Wang
Jul 21, 2021·Chemical Reviews·W Russ AlgarHyungki Kim

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