Development of a histological pseudocapsule and its use as a surgical capsule in the excision of pituitary tumors

Journal of Neurosurgery
Edward H Oldfield, Alexander O Vortmeyer

Abstract

The presence of a histological pseudocapsule around pituitary tumors was noted in the early 1900s. Since that time there has been no emphasis on the sequence of the stages of its development or on the relationship between these stages and the capacity to identify very small pituitary tumors at surgery in patients in whom preoperative imaging has been nondiagnostic. In addition, limited emphasis has been given to the pseudocapsule's use for selective and complete resection of pituitary adenomas. The development of the pseudocapsule was examined by performing histological analysis of portions of pituitary glands removed during 805 operations for Cushing disease. Twenty-five adenomas, each measuring between 0.25 and 4 mm in maximum diameter, were detected in the excised specimens; 17 were adenocorticotropic hormone-positive adenomas and eight were incidental tumors (four prolactin-secreting and four nonsecreting lesions). In 16 tumors the size of the adenoma could be established. The distribution of tumor size in relation to the presence of a histological pseudocapsule indicates a transition from the absence of a reticulin capsule (tumor diameter < or =1 mm) through the initial compression of surrounding tissue (tumor diameter 1-2...Continue Reading

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Citations

Jan 25, 2013·Neurosurgical Review·Takashi SugawaraKikuo Ohno
Nov 16, 2013·Neurosurgical Review·Mustafa BerkerAlper Gürlek
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Russell R LonserEdward H Oldfield
Feb 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Russell R LonserEdward H Oldfield
Mar 10, 2009·Journal of Neurosurgery·Jay JagannathanEdward H Oldfield
Mar 10, 2009·Journal of Neurosurgery·Martin H Weiss
Sep 20, 2011·Journal of Neurosurgery·Marc R Mayberg
May 15, 2012·Journal of Neurosurgery·Dueng-Yuan HuengChien-Min Chen
Mar 3, 2006·Journal of Neurosurgery·Edward R Laws
May 2, 2014·Postgraduate Medical Journal·Philip C JohnstonRobert J Weil
May 27, 2014·Journal of Neurosurgery·Gautam U MehtaEdward H Oldfield
Feb 21, 2008·Pituitary·Paolo CappabiancaAnnamaria Colao
Jun 15, 2014·Endocrine·Philip C JohnstonAmir H Hamrahian
Dec 17, 2014·World Neurosurgery·Paolo CappabiancaMichelangelo de Angelis
Aug 22, 2009·Acta neurochirurgica·Juan C Fernandez-MirandaAmin B Kassam
Feb 22, 2011·Acta neurochirurgica·Xin QuGuang-Ming Xu
May 21, 2013·Acta neurochirurgica·Savas CeylanCigdem Vural
Jan 29, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nicholas F MarkoRobert J Weil
Oct 8, 2011·Current Problems in Surgery·Philip W Smith, John B Hanks
Apr 16, 2011·World Neurosurgery·Gerardo Guinto BalanzarNorma Arechiga
Feb 1, 2011·World Neurosurgery·Gautam U MehtaRussell R Lonser
Nov 29, 2015·Otolaryngologic Clinics of North America·Christopher J FarrellJames J Evans
Apr 11, 2015·Journal of Neurosurgery·Edward H Oldfield, Marsha J Merrill
Jul 30, 2014·Pituitary·Eui Hyun KimSun Ho Kim
Feb 14, 2015·Journal of Neurosurgery·Mahmoud MessererEmmanuel Jouanneau
Apr 23, 2016·Journal of Neurosurgery·Russell R LonserEdward H Oldfield
Mar 1, 2015·Pituitary·Robert F DallapiazzaJohn A Jane
Jun 13, 2016·Acta neurochirurgica·Marina L Reppucci, Amir R Dehdashti
Jul 23, 2016·World Neurosurgery·Yasuyuki KinoshitaKaoru Kurisu
Jun 18, 2016·World Neurosurgery·Michael ZhangTheodore H Schwartz

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Methods Mentioned

BETA
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