Development of a LC-MS/MS Method for the Multi-Mycotoxin Determination in Composite Cereal-Based Samples

Toxins
B De SantisC Brera

Abstract

The analytical scenario for determining contaminants in the food and feed sector is constantly prompted by the progress and improvement of knowledge and expertise of researchers and by the technical innovation of the instrumentation available. Mycotoxins are agricultural contaminants of fungal origin occurring at all latitudes worldwide and being characterized by acute and chronic effects on human health and animal wellness, depending on the species sensitivity. The major mycotoxins of food concern are aflatoxin B1 and ochratoxin A, the first for its toxicity, and the second for its recurrent occurrence. However, the European legislation sets maximum limits for mycotoxins, such as aflatoxin B1, ochratoxin A, deoxynivalenol, fumonisins, and zearalenone, and indicative limits for T-2 and HT-2 toxins. Due to the actual probability that co-occurring mycotoxins are present in a food or feed product, nowadays, the availability of reliable, sensitive, and versatile multi-mycotoxin methods is assuming a relevant importance. Due to the wide range of matrices susceptible to mycotoxin contamination and the possible co-occurrence, a multi-mycotoxin and multi-matrix method was validated in liquid chromatography-tandem mass spectrometry (LC-...Continue Reading

References

Jul 15, 2003·Clinical Microbiology Reviews·J W Bennett, M Klich
Feb 21, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Rudolf KrskaColin Crews
Apr 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M MiragliaA Vespermann
Jan 25, 2011·Molecular Nutrition & Food Research·Bertrand GrenierIsabelle P Oswald
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Apr 14, 2016·Scientific Reports·P BattilaniT Robinson
Nov 5, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Francesco CubaddaAlberto Mantovani

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Citations

Apr 4, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Philana NolanKatrina Campbell
Apr 25, 2020·Foods·Sofia AgriopoulouTheodoros Varzakas
Sep 9, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shandry Mmasetshaba TebelePatrick Berka Njobeh
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena Polak-Śliwińska, Beata Paszczyk
Aug 7, 2021·Toxins·Krisztina Majer-BaranyiAndrás Székács

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Methods Mentioned

BETA
reverse phase chromatography

Software Mentioned

EURACHEM
MassLynx

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