Development of a liposomal delivery system for temperature-triggered release of a tumor targeting agent, Ln(III)-DOTA-phenylboronate

Bioorganic & Medicinal Chemistry
Kristina DjanashviliGerben A Koning

Abstract

Liposomes, capable of temperature-triggered content release at the site of interest, can be of great importance for imaging and therapy of tumors. The delivery of imaging agents or therapeutics can be improved by application of liposomes with a gel-to-liquid phase-transition temperature suitable for mild hyperthermia (41-43°C), and by prolonging their circulation time by incorporation of lipids containing polyethyleneglycol moieties. Still, the rapid wash out of the delivered material from the tumor tissue is a major obstacle for both imaging and therapy. In this study, we developed an optimized temperature sensitive liposomal system to be used with mild hyperthermia: highly stable at physiological temperature and with a sharp transition of the bilayer at 41.5°C, with subsequent rapid release of entrapped compounds such as calcein or tumor cell-targeting contrast agents. Intravital microscopy on calcein/rhodamine containing liposomes was applied to demonstrate the applicability of this system in vivo. The calcein loaded liposomes were injected iv into nude mice with a human BLM melanoma tumor implanted in a dorsal skin-fold window chamber. Arrival of the liposomes at the tumor site and content release after temperature increase...Continue Reading

References

Sep 16, 1988·Biochimica Et Biophysica Acta·J T DerksenG L Scherphof
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lars H LindnerMarc Dellian
Dec 29, 2006·Contrast Media & Molecular Imaging·Alessandro BargeFranco Fedeli
Feb 17, 2007·Contrast Media & Molecular Imaging·Kristina DjanashviliJoop A Peters
Jan 16, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Li LiGerben A Koning

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Citations

Apr 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chris OerlemansJ Frank W Nijsen
Apr 23, 2013·Drug Development and Industrial Pharmacy·Jun ChenBao-chang Cai
Sep 15, 2014·International Journal of Pharmaceutics·Jun ChenBao-chang Cai
Nov 25, 2014·Pharmaceutical Research·Chantal Al SabbaghElias Fattal
Jun 24, 2014·Scientific Reports·Takashi NakanoKeshav M Dani
Jun 12, 2019·Laser Therapy·Jaber GhorbaniAbbas Bahador
Oct 2, 2020·Organic & Biomolecular Chemistry·Jonathan MartinelliKristina Djanashvili
Aug 23, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Nitin JoshiRinti Banerjee
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jonathan MartinelliKristina Djanashvili
Jul 25, 2012·Journal of the American Chemical Society·Job BoekhovenJan H van Esch
Oct 26, 2016·Bioorganic & Medicinal Chemistry·Haroon Ur RashidHanif Ur Rehman

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