Development of a long-range surface-enhanced Raman spectroscopy ruler

Journal of the American Chemical Society
Anant Kumar SinghParesh Chandra Ray

Abstract

Optical-ruler-based distance measurements are essential for tracking biomolecular processes in a wide range of analytical biochemical applications. The normally used Förster resonance energy transfer (FRET) ruler is not useful for investigating distance-dependent properties when distances are more than 10 nm. Driven by this limitation, we have developed a long-range surface-enhanced Raman spectroscopy (SERS) optical ruler using oval-shaped gold nanoparticles and Rh6G dye-modified rigid, variable-length double-strand DNAs. The bifunctional rigid dsDNA molecule serves as the SERS-active ruler. Our experimental results show that one can tune the length of the SERS ruler between 8 and ∼18 nm by choosing the size of the oval-shaped gold nanoparticles. A possible mechanism for our observed distance-dependent SERS phenomenon is discussed using the Gersten and Nitzan model. Ultimately, our long-range SERS molecular rulers can be an important step toward understanding distance-dependent biological processes.

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Citations

Apr 19, 2013·Nano Letters·Gilles R BourretChad A Mirkin
Mar 29, 2014·Journal of Food and Drug Analysis·Zhen FanParesh C Ray
Jan 16, 2016·Sensors and Actuators. B, Chemical·Samuel S R DasaryAnant K Singh
Jul 22, 2016·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Amber M PaulParesh C Ray
Jan 18, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Stacy JonesParesh Chandra Ray
Nov 8, 2018·The Analyst·Gregory Q Wallace, François Lagugné-Labarthet
Oct 11, 2012·Chemical Communications : Chem Comm·Sadia Afrin KhanParesh Chandra Ray
Jun 7, 2014·Chemical Society Reviews·Paresh Chandra RayAvijit Pramanik
Oct 4, 2014·Faraday Discussions·Bhanu Priya Viraka NelloreParesh Chandra Ray
Nov 7, 2014·Reports on Progress in Physics·Wei Xie, Sebastian Schlücker
Apr 1, 2015·Chemical Science·Sudarson Sekhar SinhaParesh Chandra Ray
Apr 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rajashekhar KanchanapallyParesh Chandra Ray
Feb 2, 2021·ACS Applied Materials & Interfaces·Xiaojun LuoJean-Francois Masson
Dec 21, 2016·Accounts of Chemical Research·Sudarson Sekhar SinhaParesh Chandra Ray
Oct 8, 2020·Analytical Chemistry·Jun MaCheng Zhi Huang
Aug 16, 2015·The Journal of Physical Chemistry Letters·Zhen FanParesh Chandra Ray
Feb 20, 2020·ACS Sensors·Xiaotong GuoLingxin Chen

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