Development of a Management Algorithm for the Diagnosis of Cellular Fibroepithelial Lesions From Core Needle Biopsies

International Journal of Surgical Pathology
Jaehag JungEun-Kyu Kim

Abstract

Surgical excision is recommended for complete evaluation of cellular fibroepithelial lesions identified from core needle biopsy. The purpose of this study was to determine factors associated with phyllodes tumor among cellular fibroepithelial lesions from core biopsies and develop a scoring system to predict the risk of phyllodes tumor. We retrospectively reviewed clinical data of 169 breast lesions that were diagnosed as cellular fibroepithelial lesions from core needle biopsy at the Seoul National University Bundang Hospital between March 2005 and January 2013. The clinical, histopathologic, and radiologic characteristics were compared between phyllodes tumors and fibroadenomas during the final diagnosis after surgical excision. Of the 169 lesions, 17 were observed and 152 were surgically removed. After excision, final pathology revealed 60 (39.5%) fibroadenomas and 92 (60.5%) phyllodes tumors. Multivariate analysis demonstrated that age (≥40 years), stromal overgrowth, and stromal cellularity were independent factors associated with phyllodes tumors. A scoring system was developed based on a multivariate logistic regression model, and the area under the receiver operating characteristic curve was 0.828 (95% confidence interv...Continue Reading

References

Jul 9, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T-C ChaoM-F Chen
Feb 8, 2006·Journal of Clinical Pathology·R K JacklinA Darzi
Nov 7, 2006·Surgery·Mary F DillonArnold D K Hill
Jun 15, 2007·Annals of Surgical Oncology·Andrea V BarrioKimberly J Van Zee
Aug 19, 2010·Histopathology·Ana Richelia Jara-LazaroPuay Hoon Tan
Sep 16, 2011·Histopathology·Alex K H TsangGary M Tse
Dec 24, 2011·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·B R AdamietzM Meier-Meitinger
Mar 16, 2013·Micron : the International Research and Review Journal for Microscopy·Priti Prasanna MaityJyotirmoy Chatterjee
Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan

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Citations

Jun 11, 2020·International Journal of Surgical Pathology·Amélie WabikChristine Galant
May 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Puay Hoon Tan
Jan 22, 2021·The Breast Journal·Wissam ArabDavid Atallah

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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