Development of a manganese dioxide solid-phase reactor for oxidation of toxins associated with paralytic shellfish poisoning

Journal of Chromatography. a
J F Lawrence, B Wong

Abstract

Using manganese dioxide as a solid-phase oxidant, a post-column HPLC reactor for paralytic shellfish poison toxins was constructed and evaluated. Operating parameters such as reaction temperature and pH, flow-rate, reactor column size, and MnO2 particle size were studied. Based on a 3:1 signal-to-noise ratio the limits of detection for the non-hydroxylated toxins were in the sub-nanogram range, while the hydroxylated toxins were ten times less detectable. The limit of detection for saxitoxin was about 0.1 ng per injection. The repeatability of replicate injections was < or = 10% (relative standard deviation). The system was used to analyze extracts of shellfish and plankton yielding results that were in agreement with those obtained by established analytical methods. Extracts of shellfish contaminated at the regulatory limit of 0.8 microgram/g were successfully analyzed.

References

Mar 1, 1975·Journal of Agricultural and Food Chemistry·H A Bates, H Rapoport
Jun 1, 1993·Rapid Communications in Mass Spectrometry : RCM·M A QuilliamJ F Lawrence

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Citations

Apr 1, 2006·Chemical Communications : Chem Comm·Péter KeleRoger M Leblanc
Jun 16, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hamide Z Senyuva, John Gilbert
Nov 7, 2002·Journal of the American Chemical Society·Robert E GawleyRoger M Leblanc

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