Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel

Materials Science & Engineering. C, Materials for Biological Applications
A Fernández-ColinoE Gonzo

Abstract

Transversality between mathematical modeling, pharmacology, and materials science is essential in order to achieve controlled-release systems with advanced properties. In this regard, the area of biomaterials provides a platform for the development of depots that are able to achieve controlled release of a drug, whereas pharmacology strives to find new therapeutic molecules and mathematical models have a connecting function, providing a rational understanding by modeling the parameters that influence the release observed. Herein we present a mechanism which, based on reasonable assumptions, explains the experimental data obtained very well. In addition, we have developed a simple and accurate “lumped” kinetics model to correctly fit the experimentally observed drug-release behavior. This lumped model allows us to have simple analytic solutions for the mass and rate of drug release as a function of time without limitations of time or mass of drug released, which represents an important step-forward in the area of in vitro drug delivery when compared to the current state of the art in mathematical modeling. As an example, we applied the mechanism and model to the release data for acetazolamide from a recombinant polymer. Both mat...Continue Reading

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Citations

May 17, 2019·Therapeutic Delivery·Alicia Graciela CidJosé María Bermúdez
Jan 12, 2019·Drug Development and Industrial Pharmacy·Maimoona QindeelAsim Ur-Rehman
May 13, 2020·Current Drug Delivery·Alicia Graciela CidJosé María Bermúdez
Dec 17, 2020·International Journal of Nanomedicine·Jiangxiu NiuYu Gan
Jul 22, 2021·Therapeutic Delivery·María Elisa MelianJosé María Bermúdez

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