Development of a membrane oxygenator for ECMO using a novel fine silicone hollow fiber

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Akio FunakuboY Nosé

Abstract

One of the limitations of conventional silicone hollow fiber oxygenators compared with microporous membrane oxygenators is poor gas permeability. However, the silicone hollow fiber is free from plasma leakage, which is the major life limiting factor of the microporous membrane oxygenator. It has been difficult to fabricate a fine, thin hollow fiber for reduction of resistance to gas permeability because of the poor mechanical strength of conventional silicone materials. The authors developed a novel silicone material with sufficient mechanical strength, and a fine silicone hollow fiber with a diameter of 30 microns and wall thickness of 50 microns, which is approximately half that of a conventional silicone hollow fiber. Using this newly developed silicone hollow fiber, the authors developed a compact extracapillary flow membrane oxygenator. The oxygenator consists of fine silicone hollow fibers inserted in a housing made of polycarbonate. The housing is a cylindrical case, 20 cm long and 55 mm in inside diameter. The hollow fibers are cross-wound. The surface area of the membrane is 2.0 m2, and priming volume is 230 ml. Gas transfer performance of the newly developed oxygenator was evaluated by in vitro experiments. Oxygen and...Continue Reading

Citations

Oct 31, 2002·Artificial Organs·Tadashi MotomuraYukihiko Nosé
Jul 27, 2001·Journal of Biomaterials Science. Polymer Edition·M NiwaS Kubota
Oct 16, 2004·Critical Care Medicine·Stefano TrediciRonald B Hirschl
Nov 18, 2003·Artificial Organs·Tadashi MotomuraYukihiko Nosé
Feb 10, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·X M MuellerL K von Segesser
Oct 4, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kurt A DasseRichard J Gilbert
Aug 3, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Bruce F MonzykRichard J Gilbert
Feb 3, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroyoshi Kawakami
Aug 3, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J B ZwischenbergerR H Bartlett
Feb 27, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ali KhachabKhosrow Mottaghy
Jul 26, 2002·Perfusion·Joseph B Zwischenberger, Scott K Alpard

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