Development of a membrane oxygenator for long-term respiratory support and its experimental evaluation in prolonged ECMO

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
K EyaT Wada

Abstract

The authors developed a new membrane oxygenator (MO) for long-term respiratory support and evaluated its performance in animal experiments for as long as 336 hr. The MO, with a membrane area of 1.2 m2 and priming volume of 140 ml, is compact and designed to be interposed in a ventricular assist system (VAS) conduit. It is made with a novel hollow fiber membrane, in which micropores are blind-ended so that serum leakage can be prevented during prolonged use. The blood contacting surface of the MO is heparinized with a newly developed covalent bonding technique that ensures good thrombus resistance. In vivo evaluation with five adult goats was performed by installing the MO into a venoarterial or venovenous bypass circuit. No systemic anticoagulant therapy was used, except for a heparin-added fluid infusion to keep the pressure monitoring lines open (2-3 U/kg/hr). Throughout the experiments, no plasma leakage was observed, and gas transfer rates were maintained in a satisfactory range. Platelet counts did not decrease to less than 60% of levels before bypass, and hemolysis was negligible. The levels of coagulation parameters including fibrinogen, fibrin degradation products (FDP), antithrombin III (AT III), antiplasmin, prothromb...Continue Reading

Citations

Oct 4, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T KanamoriT Shinbo
May 16, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Tomonori TsukiyaYoshiyuki Taenaka
Aug 2, 2000·Critical Care Medicine·G C Carlon, A H Combs
Dec 6, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangJoseph B Zwischenberger
Mar 5, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Toshitaka YasudaSetsuo Takatani
Oct 4, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kurt A DasseRichard J Gilbert
Jun 10, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Daichi AkiyamaEisuke Tatsumi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Eisuke TatsumiH Takano
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
C NojiriT Kido
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Eisuke TatsumiH Takano
© 2021 Meta ULC. All rights reserved