Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

Human Vaccines
Stephen L HoffmanB Kim Lee Sim

Abstract

Immunization of volunteers by the bite of mosquitoes carrying radiation-attenuated Plasmodium falciparum sporozoites protects greater than 90% of such volunteers against malaria, if adequate numbers of immunizing biting sessions and sporozoite-infected mosquitoes are used. Nonetheless, until recently it was considered impossible to develop, license and commercialize a live, whole parasite P. falciparum sporozoite (PfSPZ) vaccine. In 2003 Sanaria scientists reappraised the potential impact of a metabolically active, non-replicating PfSPZ vaccine, and outlined the challenges to producing such a vaccine. Six years later, significant progress has been made in overcoming these challenges. This progress has enabled the manufacture and release of multiple clinical lots of a 1(st) generation metabolically active, non-replicating PfSPZ vaccine, the Sanaria PfSPZ Vaccine, submission of a successful Investigational New Drug application to the US Food and Drug Administration, and initiation of safety, immunogenicity and protective efficacy studies in volunteers in MD, US. Efforts are now focused on how best to achieve submission of a successful Biologics License Application and introduce the vaccine to the primary target population of Afri...Continue Reading

Citations

Sep 15, 2011·Parasitology Research·Yanhui ZhangXin-Zhuan Su
Jan 31, 2012·Tropical Animal Health and Production·Gerrit J Viljoen, Antony G Luckins
Apr 26, 2011·Lancet·Brian Greenwood, Geoffrey Targett
Feb 8, 2013·Nature Medicine·Pedro L Alonso, Marcel Tanner
Feb 8, 2013·Nature Medicine·Eleanor M Riley, V Ann Stewart
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sophie H AdjalleyDavid A Fidock
Oct 27, 2012·The Journal of Infectious Diseases·Miranda S OakleySanjai Kumar
Sep 7, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Brian GreenwoodAdrian V S Hill
Sep 7, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adrian V S Hill
Feb 11, 2012·Clinical and Vaccine Immunology : CVI·Kevin W BruhnNoah Craft
Sep 9, 2010·Infection and Immunity·Babita MahajanSanjai Kumar
Feb 23, 2013·Infection and Immunity·Bart W FaberClemens H M Kocken
Jan 11, 2012·Malaria Journal·Lauren SchwartzVasee S Moorthy
Oct 12, 2013·Malaria Journal·Geoffrey A T TargettGraham V Brown
Mar 19, 2013·Malaria Journal·Grace MwangokaSalim Abdulla
Feb 12, 2011·PLoS Medicine·UNKNOWN malERA Consultative Group on Vaccines
Feb 23, 2012·PloS One·Walter R Weiss, Chengyong George Jiang
May 3, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Alberto L García-BasteiroPedro L Alonso
Feb 15, 2011·The American Journal of Tropical Medicine and Hygiene·Alejandro Jordán-VillegasSócrates Herrera
Nov 15, 2012·The American Journal of Tropical Medicine and Hygiene·Meta RoestenbergStephen L Hoffman
Feb 11, 2014·Nature Medicine·Laurent DembéléDominique Mazier
Nov 15, 2011·Annual Review of Medicine·Mahamadou A Thera, Christopher V Plowe
Dec 3, 2010·The Journal of Clinical Investigation·Peter D CromptonLouis H Miller
Feb 18, 2011·Cellular and Molecular Life Sciences : CMLS·Michael F Good
Jul 14, 2010·Expert Review of Vaccines·Julio Vladimir Cruz-ChanEric Dumonteil
Jul 14, 2010·Expert Review of Vaccines·Cevayir CobanKen J Ishii
Nov 16, 2012·Expert Review of Vaccines·Aiala SalvadorManoli Igartua
Dec 14, 2011·Expert Review of Vaccines·Claudia A Daubenberger
Oct 5, 2013·Expert Opinion on Drug Discovery·Jana HeldBenjamin Mordmüller
Feb 13, 2016·Parasitology·Karina P De Sousa, Denise L Doolan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.