Development of a micro-distillation microfluidic paper-based analytical device as a screening tool for total ammonia monitoring in freshwaters

Analytica Chimica Acta
Jonathan J PetersSpas D Kolev

Abstract

An easy-to-use, portable 3D microfluidic paper-based analytical device (μPAD) for the determination of total ammonia (i.e., ammonia + ammonium) in freshwaters is described. It consists of two layers of paper patterned with hydrophilic circular zones, one impregnated with sodium hydroxide (sample zone) and another (detection zone) with an acid-base indicator (nitrazine yellow (NY) or bromothymol blue (BTB)), separated by a μ-distillation chamber. Ammonium ions present in the water sample are converted into ammonia gas by reaction with sodium hydroxide in the sample zone. Ammonia then diffuses through a headspace and reacts with an acid-base indicator in the detection zone, the reflectance of which can be related to the total ammonia concentration. The analytical signal at 7.8 mg L-1 offered by the μ-distillation chamber-based μPAD is more than double of that obtained using a gas-permeable membrane. The proposed μPAD is characterised by a limit of detection of 0.32 or 0.47 mg N L-1 and working concentration ranges of 0.5-3.0 mg N L-1 or 2.0-10 mg N L-1 when using NY or BTB indicators, respectively. This is the first μPAD whose working range covers almost the entire trigger value range (0.32-2.3 mg N L-1) for ammonia nitrogen in f...Continue Reading

Citations

Sep 18, 2020·Analytical Methods : Advancing Methods and Applications·Andreea Oarga MulecRadmila Milačič
Sep 9, 2020·Analytical Methods : Advancing Methods and Applications·Thinikan ThongkamKhuanjit Hemavibool
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marek Trojanowicz
Dec 31, 2020·Sensors·Raquel Catalan-CarrioFernando Benito-Lopez
Jul 3, 2021·Biosensors·Adrià Martínez-AviñóPilar Campíns-Falcó

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