Development of a model of tissue with potentially malignant disorders (PMD) in the hamster cheek pouch to explore the long-term potential therapeutic and/or toxic effects of different therapeutic modalities

Archives of Oral Biology
Elisa M HeberAmanda E Schwint

Abstract

Given that locoregional recurrences developing from a tissue with potentially malignant disorders (PMD) in oral mucosa are a frequent cause of therapeutic failure, and that tissue with PMD is dose-limiting, the aim of the present study was to develop a model of tissue with PMD to evaluate the long-term therapeutic/toxic effects of different therapeutic modalities. We evaluated 5 carcinogenesis protocols based on topical application of the carcinogen dimethyl-1,2-benzanthracene in the hamster cheek pouch, twice a week for 4, 6, 7, and 8 weeks and the classical 3 times a week for 12 weeks. Long-term follow-up (8 months after protocol completion) was only possible with the 4- and 6-week carcinogenesis protocols. Tumour development increased progressively with time and aggressiveness of the carcinogenesis protocols. The time at which tumours developed in > or =90% of the animals was at protocol completion (T0) for the 12-week protocol, 1 month post-T0 for the 8-week protocol, 3 months post-T0 for the 7-week protocol and 4 months post-T0 for the 6-week protocol. <40% of the animals in the 4-week protocol developed tumours within the 8 months follow-up period. DNA synthesis rose as a function of time and protocol aggressiveness. The ...Continue Reading

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Citations

Dec 24, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Marcela A GarabalinoAmanda E Schwint
Apr 18, 2013·Radiation and Environmental Biophysics·Marcela A GarabalinoAmanda E Schwint
Dec 17, 2014·Periodontology 2000·Andrea Monti-HughesMaria E Itoiz
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Elisa M HeberAmanda E Schwint
Sep 2, 2014·Clinical and Experimental Otorhinolaryngology·Vinícius Faccin BampiLaura Beatriz Oliveira de Oliveira
Apr 17, 2020·Oral Diseases·Iara S Santa CruzAndrea Monti Hughes

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