Development of a modeling pipeline for the prediction of hemodynamic outcome after virtual mitral valve repair using image-based CFD

International Journal of Computer Assisted Radiology and Surgery
Katharina VellguthTitus Kuehne

Abstract

Severe mitral valve regurgitation can either be treated by a replacement or a repair of the valve. The latter is recommended due to lower perioperative mortality and better long-term survival. On the other hand, recurrence rates after mitral valve repair are high compared to those after replacements and the repair intervention can cause induced mitral valve stenosis. So far, there are no methods to predict the hemodynamic outcome of a chosen treatment or to compare different treatment options in advance. To overcome this, diastolic mitral valve hemodynamics are simulated using computational fluid dynamics after different virtual treatments of the valve. The left ventricular geometry of one patient was reconstructed using trans-esophageal echocardiography and computed tomography data. Pre-op hemodynamics are simulated using a referenced wall model to avoid expansive modeling of wall motion. Subsequently, the flow structures are compared to in vivo measurements. After manipulating the patient-specific geometry in order to mimic a restrictive mitral annuloplasty as well as a MitraClip intervention, hemodynamics results are calculated. Good agreements exist between calculated pre-op hemodynamics and in vivo measurements. The virtua...Continue Reading

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Citations

Jun 21, 2019·International Journal of Computer Assisted Radiology and Surgery·Katharina VellguthLeonid Goubergrits
May 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Mohammadali HedayatIman Borazjani
Aug 9, 2020·Journal of Biomechanical Engineering·Fanwei Kong, Shawn C Shadden
Jul 1, 2020·Biomedizinische Technik. Biomedical Engineering·Anna DaubBettina Frohnapfel
Feb 25, 2021·Expert Review of Medical Devices·Karel M Van PraetVolkmar Falk

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