Development of a modified - solid dispersion in an uncommon approach of melting method facilitating properties of a swellable polymer to enhance drug dissolution

International Journal of Pharmaceutics
Tuong Ngoc-Gia NguyenThao Truong-DinhTran

Abstract

The study aimed to develop a modified-solid dispersion method using a swellable hydrophilic polymers accompanied by a conventional carrier to enhance the dissolution of a drug that possesses poor water solubility. Two swellable polymers (hydroxypropyl methylcellulose and polyethylene oxide) were swelled in melted polyethylene glycol 6000 (PEG 6000) in different ratios and under different conditions. The type, amount, and, especially, incorporation method of the swellable polymers were crucial factors affecting the dissolution rate, crystallinity, and molecular interaction of the drug. Interestingly, the method in which the swellable polymer was thoroughly mixed with the melted PEG 6000 as the first step was more effective in increasing drug dissolution than the method in which the drug was introduced to the melted PEG 6000 followed by the addition of the swellable polymer. This system has potential for controlling drug release due to high swelling capabilities of these polymers. Therefore, the current study can be considered to be a promising model for formulations of controlled release systems containing solid dispersions.

References

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Citations

Aug 13, 2015·Pharmaceutical Research·Tuong Ngoc-Gia NguyenThao Truong-Dinh Tran
Aug 27, 2015·Drug Delivery and Translational Research·Dinesh Kumar MishraPradyumna Kumar Mishra
Oct 25, 2016·International Journal of Pharmaceutics·Hai Van NgoThao Truong-Dinh Tran
Mar 17, 2017·AAPS PharmSciTech·Minh Nguyet PhamThao Truong-Dinh Tran
Apr 2, 2017·International Journal of Pharmaceutics·Joanna SzafraniecRenata Jachowicz
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Duong T T PhamThao T D Tran
Jul 10, 2020·Anti-cancer Agents in Medicinal Chemistry·Phuong H L Tran, Thao T D Tran

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