Development of a modified acetonitrile-based extraction procedure followed by ultra-high performance liquid chromatography-tandem mass spectrometry for the analysis of psychiatric drugs in sediments

Journal of Chromatography. a
Lúcia H M L M SantosCristina Delerue-Matos

Abstract

An analytical method based on a modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) extraction procedure followed by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed for the analysis of psychiatric drugs in sediments. An optimized approach was applied in sample preparation by using basic acetonitrile as extraction solvent. Extraction was followed by a clean-up using dispersive solid phase extraction (dSPE) to remove matrix interfering compounds. The analytical method was validated in terms of sensitivity, linearity, recovery, intra- and inter-day precisions and method detection and quantification limits. Under optimized conditions, limits of detection ranged from 0.01ngg(-1) to 2.08ngg(-1); and recoveries between 47 and 110% with relative standard deviation (RSD) below 5%. The developed methodology was applied to sediments of two Portuguese rivers (Douro and Lima rivers) and nine out of eleven psychiatric drugs were detected in sediments at concentrations up to 26.4ngg(-1) (dry weight). To the best of our knowledge, it was the first time that the human metabolites norfluoxetine and norsertraline were detected in river sediments at levels of few nanograms per gram.

References

Feb 8, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·R Cueva-MestanzaJ J Santana-Rodríguez
Dec 22, 2009·Environment International·Silvia González AlonsoYolanda Valcárcel
Aug 25, 2010·The Science of the Total Environment·Tânia Vieira MadureiraMaria Elizabeth Tiritan
Jul 17, 2012·The Science of the Total Environment·Idalina BragançaCristina Delerue-Matos
Sep 4, 2012·The Science of the Total Environment·Liliana J G SilvaAngelina Pena
Jun 5, 2013·The Science of the Total Environment·Lúcia H M L M SantosM Conceição B S M Montenegro
Nov 22, 2013·Analytical and Bioanalytical Chemistry·Alexandra Berlioz-BarbierCécile Cren-Olivé
Jan 11, 2014·Journal of Agricultural and Food Chemistry·Laura J CarterAlistair B A Boxall
Mar 19, 2014·Ecotoxicology and Environmental Safety·Joanna Giebułtowicz, Grzegorz Nałęcz-Jawecki
Apr 29, 2014·Analytical and Bioanalytical Chemistry·Maria Concetta BruzzonitiMassimo Del Bubba
Nov 14, 2014·Critical Reviews in Analytical Chemistry·Cláudia RibeiroMaria Elizabeth Tiritan
Feb 25, 2015·Environmental Science and Pollution Research International·Solomon MatongoPatrick Ndungu

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Citations

Sep 21, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Glenn LoosDeirdre Cabooter
Oct 4, 2016·Environmental Science and Pollution Research International·Jakub Trawiński, Robert Skibiński
Jan 10, 2019·Analytical and Bioanalytical Chemistry·Christina I NannouTriantafyllos A Albanis
Feb 3, 2018·Analytical and Bioanalytical Chemistry·Christina I NannouTriantafyllos A Albanis
Mar 20, 2021·The Science of the Total Environment·Jesús Daniel Cardoso-VeraLeobardo Manuel Gómez-Oliván
Aug 12, 2021·Environmental Toxicology and Chemistry·Jamie HarrowerKarin Helwig

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