Development of a molecularly imprinted solid-phase extraction sorbent for the selective extraction of telmisartan from human urine

Journal of Separation Science
Hüma Yılmaz, Hasan Basan

Abstract

A novel molecularly imprinted solid-phase extraction with spectrofluorimetry method has been developed for the selective extraction of telmisartan from human urine. Molecularly imprinted polymers were prepared by a noncovalent imprinting approach through UV-radical polymerization using telmisartan as a template molecule, 2-dimethylamino ethyl methacrylate as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, N,N-azobisisobutyronitrile as an initiator, chloroform as a porogen. Molecularly imprinted polymers and nonimprinted control polymer sorbents were dry-packed into solid-phase extraction cartridges, and eluates from cartridges were analyzed using a spectrofluorimeter. Limit of detection and limit of quantitation values were 11.0 and 36.0 ng/mL, respectively. A very high imprinting factor (16.1) was achieved and recovery values for the telmisartan spiked in human urine were in the range of 76.1-79.1%. In addition, relatively low within-day (0.14-1.6%) and between-day (0.11-1.31%) precision values were obtained. Valsartan was used to evaluate the selectivity of sorbent as well. As a result, a sensitive, selective, and simple molecularly imprinted solid-phase extraction with spectrofluorimetry method has be...Continue Reading

References

Aug 8, 2001·Journal of Pharmaceutical and Biomedical Analysis·E CagigalR M Jiménez
Oct 6, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jing NieYu-Qi Feng
Jan 3, 2013·Journal of Separation Science·Won Jo CheongFaiz Ali
Jun 20, 2013·Pharmaceutical Methods·Kaliappan Ilango, Pushpangadhan S Shiji Kumar

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Citations

Mar 5, 2016·Journal of Separation Science·Tyge Greibrokk
Jun 15, 2016·Journal of Separation Science·Agnieszka IwanowskaKrzysztof Szczubiałka
Nov 9, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mariana Roberto Gama, Carla Beatriz Grespan Bottoli

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