Development of a more thermostable poliovirus vaccine

The Journal of Infectious Diseases
J B MilstienP F Wright


In 1991, a goal of improved thermostability of oral poliovirus vaccine (OPV) was set, and the Product Development Group was established under the Children's Vaccine Initiative to achieve this goal. Several initial research strategies were unsuccessful. The substitution of deuterium oxide for water in the final blending stage of vaccine production resulted in a significantly more stable product at temperatures of > or = 37 degrees C. A large body of clinical data shows the safety of deuterium at the dosage that would be given with this vaccine. However, reservations about the public acceptability of the vaccine, combined with the progress achieved in polio eradication with the current vaccine and the availability of vaccine vial monitors to indicate time and temperature exposure of every vial of OPV, have resulted in a recommendation that vaccine development cease. This product development activity has been instructive for the process of introduction of new vaccines.


Oct 12, 2000·Vaccine·S C Arya
Sep 25, 2001·Vaccine·S E RobertsonB Ivanoff
Jan 31, 2002·Vaccine·Mine R Ikizler, Peter F Wright
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guangchuan WangCheng-Feng Qin
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V M Cáceres, R W Sutter
Nov 28, 2013·Journal of Pharmaceutical Sciences·Wei QiC Russell Middaugh
Sep 16, 2004·Journal of Medical Virology·Hiroshi ShiomiKoki Taniguchi
Aug 9, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kevin J McHughAna Jaklenec
Apr 26, 2013·Vaccine·Debra Kristensen, Dexiang Chen
Jul 6, 2014·Biologicals : Journal of the International Association of Biological Standardization·Ozan S KumruDavid B Volkin
Feb 1, 2000·Biologicals : Journal of the International Association of Biological Standardization·J B MilstienE Griffiths
Dec 23, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Walter DowdleChris Wolff
Sep 24, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Rhys B MurphyTamim A Darwish
Nov 19, 2013·Pharmaceutical Patent Analyst·Ahd Hamidi, Wilfried A M Bakker
Feb 28, 2007·The Journal of General Virology·Roberto MateoMauricio G Mateu
May 1, 2018·Advanced Biosystems·Marieh B Al-HandawiPanče Naumov
Apr 10, 2021·Applied Microbiology and Biotechnology·Ravinder Kumar, Bhushan N Kharbikar

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.