Development of a multifunctional gold nanoplatform for combined chemo-photothermal therapy against oral cancer.

Nanomedicine
Zengying LiuQin Xu

Abstract

Aim: To design and fabricate a multifunctional drug-delivery nanoplatform for oral cancer therapy. Materials & methods: Polyethylene glycol-stabilized, PDPN antibody (PDPN Ab)- and doxorubicin (DOX)-conjugated gold nanoparticles (AuNPs) were prepared and evaluated for their cytotoxicity and antitumor efficacy in both chemotherapy and photothermal therapy. Results: The obtained (PDPN Ab)-AuNP-DOX system presents low toxicity, a high drug loading capacity and cellular uptake efficiency. Both in vitro and in vivo experiments demonstrate that (PDPN Ab)-AuNP-DOX has enhanced antitumor efficacy. Treatment with (PDPN Ab)-AuNP-DOX combined with laser irradiation exhibits superior antitumor effects. Conclusion: This (PDPN Ab)-AuNP-DOX system may be used as a versatile drug-delivery nanoplatform for targeted and combined chemo-photothermal therapy against oral cancer.

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Citations

Oct 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhangfan DingHuixu Xie
Jan 5, 2021·Frontiers in Pharmacology·Zhilong ZhaoCongxiao Zhang
Jan 28, 2021·Drug Delivery·Jingou LiangLei Cheng
Feb 27, 2021·Biomaterials Science·Feifei WangHongbo Zeng
Mar 26, 2021·Molecular Cancer·Tina BriolayNicolas Boisgerault
May 14, 2021·Bioinorganic Chemistry and Applications·Weiping ZhengChangqing Yuan
Jun 22, 2021·Seminars in Cancer Biology·Serenella MediciMaria Antonietta Zoroddu
Jul 6, 2021·International Journal of Biological Macromolecules·Jamileh KadkhodaAyuob Aghanejad
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira

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Methods Mentioned

BETA
surgical resection
infrared spectroscopy
transmission electron microscopy
flow cytometry
xenograft

Software Mentioned

SPSS

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