Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment.

Pharmaceutical Research
Lieselotte De SmetChris Vervaet

Abstract

To develop a nanocrystalline paclitaxel formulation with a high paclitaxel-to-stabilizer ratio which can be used for hyperthermic intraperitoneal chemotherapy (HIPEC). Paclitaxel (PTX) nanocrystals were prepared via wet milling using Pluronic F127(®) as stabilizer. The suitability of paclitaxel nanosuspensions for HIPEC treatment was evaluated by analyzing the cytotoxicity of both stabilizer and formulation, and by determining the maximum tolerated dose (MTD) and bioavailability. The effect on tumor growth was evaluated by magnetic resonance imaging (MRI) at day 7 and 14 after HIPEC treatment in rats with peritoneal carcinomatosis of ovarian origin. Monodisperse nanosuspensions (±400 nm) were developed using Pluronic F127(®) as single additive. The cytotoxicity and MTD of this nanocrystalline formulation was similar compared to Taxol(®), while its bioavailability was higher. MRI data after HIPEC treatment with a PTX nanocrystalline suspension showed a significant reduction of tumor volume compared to the non-treated group. Although no significant differences on tumor volume were observed between Taxol(®) and the nanosuspension, the rats treated with the nanosuspension recovered faster following the HIPEC procedure. Nanosuspensi...Continue Reading

References

Aug 31, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H GelderblomA Sparreboom
Sep 3, 2002·Advanced Drug Delivery Reviews·Alexander V KabanovValery Yu Alakhov
May 7, 2003·The Lancet Oncology·Maurie Markman
Nov 11, 2006·Pharmaceutical Research·Gilles DumortierJean Claude Chaumeil
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K FujiwaraM Markman
Oct 22, 2008·Gynecologic Oncology·Robert E BristowDennis S Chi
Jan 16, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V BatrakovaAlexander V Kabanov
Feb 2, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayE Steliarova-Foucher
Mar 4, 2010·Pharmaceutical Research·Gaurav Bajaj, Yoon Yeo
Jun 22, 2010·Journal of Pharmaceutical Sciences·Feng LiuLeaf Huang
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Leena Peltonen, Jouni Hirvonen
Apr 5, 2011·International Journal of Pharmaceutics·Peng LiuLeena Peltonen
Apr 21, 2011·Current Oncology·F MohamedP Sugarbaker

❮ Previous
Next ❯

Citations

Jan 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying LuMichael Sturek
May 27, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fabienne DanhierVéronique Préat
May 23, 2014·Pharmaceutical Research·Pieter ColinAn Vermeulen
May 7, 2013·Current Opinion in Solid State & Materials Science·Bo Sun, Yoon Yeo
Oct 15, 2013·Journal of Surgical Oncology·Félix GremonprezWim Ceelen
Mar 19, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·A HillK Mäder
Jul 17, 2016·Advanced Drug Delivery Reviews·George R DakwarKatrien Remaut
Aug 23, 2016·ACS Applied Materials & Interfaces·Dae Gon LimSeong Hoon Jeong
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lieselotte LemoineKurt Van der Speeten
Oct 19, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaoqing MiaoPeng Huang
Jun 1, 2017·Pleura and Peritoneum·Joji KitayamaNaohiro Sata
Nov 7, 2020·International Journal of Pharmaceutics·Pétronille RoyVincent Boudy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.