Development of a new delivery system consisting in 'drug-in cyclodextrin-in PLGA nanoparticles'

Journal of Microencapsulation
P MuraAntonio Almeida

Abstract

A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-betaCD-loaded NPs) up to 100% (drug-methylbetaCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.

References

May 1, 1995·Current Opinion in Rheumatology·L S Simon
May 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·A G Hausberger, P P DeLuca
Dec 17, 1998·The American Journal of Medicine·R Rothstein
Feb 9, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J Filipović-GrcićI Jalsenjak
Apr 18, 2000·Journal of Pharmaceutical and Biomedical Analysis·K V ReddyG O Reddy
Feb 19, 2002·Chemical Reviews·Kaneto UekamaTetsumi Irie
Jan 25, 2005·International Journal of Pharmaceutics·Rubiana M Mainardes, Raul C Evangelista
Jun 28, 2005·The Journal of Pharmacology and Experimental Therapeutics·Alf LamprechtYoshiaki Kawashima
Mar 11, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Francesca MaestrelliMaria José Alonso
May 6, 2006·International Journal of Pharmaceutics·Yvette MeissnerAlf Lamprecht
Dec 2, 2006·International Journal of Pharmaceutics·Thorsteinn Loftsson, Dominique Duchêne
Dec 13, 2006·International Journal of Pharmaceutics·Carolina Gómez-GaeteElias Fattal
Mar 25, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·F MaestrelliP Mura
Apr 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiangrong SongQiuhong Chen

❮ Previous
Next ❯

Citations

Dec 18, 2013·International Journal of Pharmaceutics·Nadiah ZafarAbdelhamid Elaissari
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Farha MasoodMuhammad Mujahid
Jan 5, 2012·Journal of Microencapsulation·Chaoyong LiuJing Sheng
May 18, 2016·International Journal of Pharmaceutics·Paola MuraCésar Viseras
Mar 7, 2021·Biomolecules·Gustavo Marinho MirandaJaime Ribeiro-Filho
May 29, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilya YakavetsLina Bezdetnaya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved