Development of a novel clinical staging model for cirrhosis using the Nationwide Inpatient Sample

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Mona HajDon C Rockey

Abstract

Scoring systems such as Model for End-stage Liver Disease (MELD) and Child-Pugh are often used by clinicians to determine prognosis in patients with cirrhosis. Since clinical complications are important in determining cirrhosis outcomes, our goal was to use these to develop a novel prognostic staging model. Data from the Nationwide Inpatient Sample (NIS), years 2003-2011, were queried for records of patients over the age of 18 with cirrhosis excluding patients with prior or inpatient liver transplantation. The primary outcome was inpatient mortality with focus on cirrhosis-related complications: non-bleeding esophageal varices, variceal hemorrhage, ascites, hepatic encephalopathy (HE), spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS). Of 59 862 903 hospitalizations, 824 783 (1.4%) with cirrhosis were identified. Overall mortality was 7% with two-thirds (66%) of deaths occurring in patients with a decompensating event, defined as variceal hemorrhage, ascites, HE, SBP, and/or HRS. Overall mortality rates decreased from 2003 to 2011 (9.0-6.0%), in both compensated and decompensated groups. Mortality was higher in patients with variceal haemorrhage (OR 1.56; p<0.05), HE (OR 1.75; p<0.05), SBP (OR 2.64; p<0.05...Continue Reading

References

Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brennan M r SpiegelIan M Gralnek
Dec 5, 2003·Lancet·Pere GinèsJuan Rodés
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roberto J Groszmann, Suchat Wongcharatrawee
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicolas CarbonellRaoul Poupon
Nov 25, 2005·The New England Journal of Medicine·Roberto J GroszmannUNKNOWN Portal Hypertension Collaborative Group
Aug 31, 2007·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of American College of Gastroenterology
Oct 2, 2007·Gastrointestinal Endoscopy·Brennan M R SpiegelGlenn Eisen
Feb 23, 2008·Seminars in Liver Disease·Jaime BoschJuan Carlos Garcia-Pagan
Jan 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoMassimo Pinzani
Nov 26, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Anand SinglaShimul A Shah
May 31, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maria StepanovaZobair M Younossi
Jun 12, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Alexander ZipprichMatthias M Dollinger
Mar 25, 2014·Alimentary Pharmacology & Therapeutics·G D'AmicoL Pagliaro
Mar 11, 2016·World Journal of Hepatology·Chalermrat BunchorntavakulDisaya Chavalitdhamrong
Nov 8, 2017·Journal of Hepatology·Gennaro D'AmicoMaria Grazia Valsecchi

❮ Previous
Next ❯

Citations

Aug 3, 2019·Journal of Clinical Gastroenterology·Mohammad BilalDon C Rockey
Feb 3, 2021·Gastroenterology·Don C Rockey, Scott L Friedman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Gastroenterology
Robert S Rahimi, Don C Rockey
Current Opinion in Gastroenterology
Robert S Rahimi, Don C Rockey
The Medical Clinics of North America
Iris W Liou
Current Opinion in Gastroenterology
Robert S Rahimi, Don C Rockey
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Hui MaLai Wei
© 2022 Meta ULC. All rights reserved