Development of a novel keratin dressing which accelerates full-thickness skin wound healing in diabetic mice: In vitro and in vivo studies

Journal of Biomaterials Applications
Marek KonopLidia Rudnicka

Abstract

Impaired wound healing is a major medical problem in diabetes. The objective of this study was to determine the possible application of an insoluble fraction of fur-derived keratin biomaterial as a wound dressing in a full thickness surgical skin wound model in mice ( n = 20) with iatrogenically induced diabetes. The obtained keratin dressing was examined in vitro and in vivo. In vitro study showed the keratin dressing is tissue biocompatible and non-toxic for murine fibroblasts. Antimicrobial examination revealed the keratin dressing inhibited the growth of S. aureus and E. coli. In vivo studies showed the obtained dressing significantly ( p < 0.05) accelerated healing during the first week after surgery compared to control wounds. Keratin dressings were incorporated naturally into granulation and regenerating tissue without any visible signs of inflammatory response, which was confirmed by clinical and histopathological analysis. It is one of the first studies to show application of insoluble keratin proteins and its properties as a wound dressing. The obtained keratin dressing accelerated wound healing in mice with iatrogenically induced diabetes. Therefore, it can be considered as a safe and efficient wound dressing. Althou...Continue Reading

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Citations

Apr 3, 2019·Journal of Tissue Engineering and Regenerative Medicine·Che-Wei LinJiashing Yu
Aug 28, 2020·Journal of Biomaterials Applications·Marc ThompsonMark Van Dyke
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marek KonopJoanna Czuwara

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