Development of a Novel, Multi-Parametric, MRI-Based Radiomic Nomogram for Differentiating Between Clinically Significant and Insignificant Prostate Cancer

Frontiers in Oncology
Yongsheng ZhangMaosheng Xu

Abstract

Objectives: To develop and validate a predictive model for discriminating clinically significant prostate cancer (csPCa) from clinically insignificant prostate cancer (ciPCa). Methods: This retrospective study was performed with 159 consecutively enrolled pathologically confirmed PCa patients from two medical centers. The dataset was allocated to a training group (n = 54) and an internal validation group (n = 22) from one center along with an external independent validation group (n = 83) from another center. A total of 1,188 radiomic features were extracted from T2WI, diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) images derived from DWI for each patient. Multivariable logistic regression analysis was performed to develop the model, incorporating the radiomic signature, ADC value, and independent clinical risk factors. This was presented using a radiomic nomogram. The receiver operating characteristic (ROC) curve was utilized to assess the predictive efficacy of the radiomic nomogram in both the training and validation groups. The decision curve analysis was used to evaluate which model achieved the most net benefit. Results: The radiomic signature, which was made up of 10 selected features, was sig...Continue Reading

References

Oct 3, 2015·European Urology·Jeffrey C WeinrebSadna Verma
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Apr 18, 2016·European Radiology·Marina Mat BakiShonit Punwani
May 4, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yan-Qi HuangZai-Yi Liu
Jul 9, 2016·Journal of Magnetic Resonance Imaging : JMRI·Matthew D GreerBaris Turkbey
Sep 14, 2016·European Radiology·Harbir S SidhuShonit Punwani
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Rakesh ShiradkarAnant Madabhushi
May 23, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Peter H Carroll, James L Mohler
Sep 20, 2018·Journal of Magnetic Resonance Imaging : JMRI·Tong ChenJunkang Shen
Jan 9, 2019·Frontiers in Oncology·Ahmad ChaddadBoris Bahoric
Jan 29, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D DongJ-F Ji

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Citations

Aug 23, 2020·Diagnostics·Angelo PorrecaMatteo Ferro

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Methods Mentioned

BETA
biopsy
biopsies
feature extraction

Software Mentioned

AK Intelligence Kit
SNAP
SPSS
pROC
mRMR
LASSO
Prostate Imaging and Reporting and Data System
rmda
ITK

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