Development of a novel oral jelly formulation for elderly patients

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Tsutomu HaradaTakayuki Owaki

Abstract

Deterioration of the swallowing function in elderly persons and drug refusal among the behavioral abnormalities in Alzheimer's disease (AD) are commonly reported. Therefore, we developed an easy-to-swallow jelly formulation of Donepezil HCl which AD patients can take as a dessert. The development process, however, was full of trade-off problems. (1) Need for evaluating the taste of a drug product vs. Safety of human sensory evaluation of the taste. The trade-off was resolved by using a taste sensor. (2) Speed of development vs. Safety of the manufacturing process. We put priority on the safety rather than speed, and a safer antioxidant agent was found. (3) Usability of the container for AD patients with dysphagia vs. Size of the container. We put priority on its being user-friendly rather than on the size and chose a stable wide-mouth cup. (4) Suitable texture of jelly for swallowing the drug product vs. Residual volume of jelly in the cup. We designed the texture so that the residual volume of jelly in the cup was reduced. (5) Easy peeling properties of aluminum seal vs. High sealing strength for sterilization. The sealing strength was adjusted so that it was adequate to sterilize the drug product. (6) One cup in a heat-sealed...Continue Reading

References

Jan 1, 1993·Journal of Geriatric Psychiatry and Neurology·W DuJ H Growdon
Jun 4, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mineka YoshikawaTeruki Komatsu

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Citations

Oct 12, 2016·Chemical & Pharmaceutical Bulletin·Yoshihiro HishikawaHirofumi Takeuchi

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