Development of a novel prognostic score for breast cancer patients using mRNA expression of CHAC1

Journal of Comparative Effectiveness Research
Beate JahnUwe Siebert

Abstract

To develop a prognostic score for primary breast cancer patients integrating conventional predictors and the novel biomarker CHAC1 to aid adjuvant chemotherapy decisions. A prognostic score for overall survival was developed using: conventional predictors from a dataset of 1777 patients and the weight of CHAC1 mRNA expression from an independent dataset of 106 patients using multivariate Cox regression. The new score includes: CHAC1 mRNA expression, age, tumor size, HER2 neu status, lymph node status and degree of malignancy. Using a cut-off value of 11 score points, 10-year survival was 82% in low-risk (n = 34) and 43% in high-risk patients (n = 72). The addition of CHAC1 resulted in 16% reclassification. Including CHAC1 in prognostic prediction may aid (and change) personalized treatment selection.

References

Oct 1, 1987·British Journal of Cancer·J H ToddJ L Haybittle
Mar 1, 1982·British Journal of Cancer·J L HaybittleK Griffiths
Apr 7, 2000·Breast Cancer Research and Treatment·P M FernandezS R Patierno
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Aug 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Peter S GargalovicAldons J Lusis
Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter ScrivenLynda Wyld
Mar 23, 2007·Breast Cancer Research and Treatment·Isabelle SoerjomataramJan Willem W Coebergh
Dec 18, 2008·Source Code for Biology and Medicine·Zoran BursacDavid W Hosmer
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Imran N MungrueAldons J Lusis
Nov 4, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wolfgang KemmnerKatharina Detjen
Dec 22, 2011·Journal of the National Comprehensive Cancer Network : JNCCN·Phillip G FebboMarian L Birkeland
Aug 21, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Mike PauldenMurray Krahn
Mar 28, 2017·Scientific Reports·Esther Paredes-AracilVicente Francisco Gil-Guillén

❮ Previous
Next ❯

Methods Mentioned

BETA
reverse
Assay

Software Mentioned

tile
SAS
Adjuvant Online
Cutoff Finder

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved