Development of a PCL/gelatin/chitosan/β-TCP electrospun composite for guided bone regeneration

Progress in Biomaterials
Masoumeh EzatiShahab Faghihi

Abstract

Many approaches have been developed to regenerate biological substitutes for repairing damaged tissues. Guided bone/tissue regeneration (GBR/GTR) that employs a barrier membrane has received much attention in recent years. Regardless of substantial efforts for treatment of damaged tissue in recent years, an effective therapeutic strategy is still a challenge for tissue engineering researchers. The aim of the current study is to fabricate a GBR membrane consisting of polycaprolactone (PCL)/gelatin/chitosan which is modified with different percentages of β-tricalcium phosphate (β-TCP) for improved biocompatibility, mechanical properties, and antibacterial activity. The membranes are examined for their mechanical properties, surface roughness, hydrophilicity, biodegradability and biological response. The mechanical properties, wettability and roughness of the membranes are improved with increases in β-TCP content. An increase in the elastic modulus of the substrates is obtained as the amount of β-TCP increases to 5% (145-200 MPa). After 5 h, the number of attached cells is enhanced by 30%, 40% and 50% on membranes having 1%, 3% and 5% β-TCP, respectively. The cell growth on a membrane with 3% of β-TCP is also 50% and 20% higher th...Continue Reading

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Citations

Dec 14, 2019·Annals of Plastic Surgery·Nan-Chieh HuangNiann-Tzyy Dai
Jul 12, 2020·International Journal of Molecular Sciences·Ju-Won KimSoo-Hwan Byun
Sep 26, 2020·International Journal of Molecular Sciences·Ho-Kyung LimSoo-Hwan Byun
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Jan 19, 2021·ACS Biomaterials Science & Engineering·Hee Yun JangJin Ho Lee

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Methods Mentioned

BETA
AFM
X-ray
scanning electron microscopy
PCR

Software Mentioned

Image Analysis J
GraphPad Prism
Image Analyzer

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