Development of A Physical Windkessel Module to Re-Create In-Vivo Vascular Flow Impedance for In-Vitro Experiments

Cardiovascular Engineering and Technology
Ethan Kung, C A Taylor

Abstract

To create and characterize a physical Windkessel module that can provide realistic and predictable vascular impedances for in-vitro flow experiments used for computational fluid dynamics validation, and other investigations of the cardiovascular system and medical devices. We developed practical design and manufacturing methods for constructing flow resistance and capacitance units. Using these units we assembled a Windkessel impedance module and defined its corresponding analytical model incorporating an inductance to account for fluid momentum. We tested various resistance units and Windkessel modules using a flow system, and compared experimental measurements to analytical predictions of pressure, flow, and impedance. The resistance modules exhibited stable resistance values over wide ranges of flow rates. The resistance value variations of any particular resistor are typically within 5% across the range of flow that it is expected to accommodate under physiologic flow conditions. In the Windkessel impedance modules, the measured flow and pressure waveforms agreed very favorably with the analytical calculations for four different flow conditions used to test each module. The shapes and magnitudes of the impedance modulus and...Continue Reading

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Citations

Nov 19, 2015·Cardiovascular Engineering and Technology·Jian ZhouUNKNOWN MOCHA Investigators
Nov 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Bryan GellnerMitesh V Badiwala
Aug 30, 2018·PloS One·Jennifer YourkavitchStephen Delgado
Mar 18, 2016·Cardiovascular Engineering and Technology·Rafeed A ChaudhuryDavid H Frakes
May 7, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marija VukicevicUNKNOWN MOCHA Network
Mar 16, 2011·Annals of Biomedical Engineering·Ethan O KungCharles A Taylor
Oct 28, 2016·Journal of Biomechanical Engineering·Rahul Raj MechoorEthan Kung
Dec 5, 2019·Cardiovascular Engineering and Technology·Bryan GellnerMitesh V Badiwala
Nov 5, 2016·Journal of Biomechanical Engineering·Vitaly O KheyfetsRobin Shandas
Dec 24, 2017·Journal of Medical Systems·Liming XinMitesh V Badiwala
Nov 19, 2015·Cardiovascular Engineering and Technology·Jeffrey S LillieDavid A Borkholder
Mar 25, 2011·Journal of Biomechanical Engineering·Ethan O KungCharles A Taylor
Nov 6, 2018·Journal of Biomechanics·John GounleyAmanda Randles

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