Development of a portable mini-generator to safely produce nitric oxide for the treatment of infants with pulmonary hypertension

Nitric Oxide : Biology and Chemistry
Binglan YuDonald B Bloch

Abstract

To test the safety of a novel miniaturized device that produces nitric oxide (NO) from air by pulsed electrical discharge, and to demonstrate that the generated NO can be used to vasodilate the pulmonary vasculature in rabbits with chemically-induced pulmonary hypertension. A miniature NO (mini-NO) generator was tested for its ability to produce therapeutic levels (20-80 parts per million (ppm)) of NO, while removing potentially toxic gases and metal particles. We studied healthy 6-month-old New Zealand rabbits weighing 3.4 ± 0.4 kg (mean ± SD, n = 8). Pulmonary hypertension was induced by chemically increasing right ventricular systolic pressure to 28-30 mmHg. The mini-NO generator was placed near the endotracheal tube. Production of NO was triggered by a pediatric airway flowmeter during the first 0.5 s of inspiration. In rabbits with acute pulmonary hypertension, the mini-NO generator produced sufficient NO to induce pulmonary vasodilation. Potentially toxic nitrogen dioxide (NO2) and ozone (O3) were removed by the Ca(OH)2 scavenger. Metallic particles, released from the electrodes by the electric plasma, were removed by a 0.22 μm filter. While producing 40 ppm NO, the mini-NO generator was cooled by a flow of air (70 ml/min...Continue Reading

References

Oct 1, 1994·Journal of the American College of Cardiology·M J SemigranM A Fifer
Jul 28, 2006·The New England Journal of Medicine·Roberta A BallardUNKNOWN NO CLD Study Group
Aug 23, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Nimish Subhedar, Chris Dewhurst
Apr 18, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhi-Kun ZhengJin-Song Li
Feb 12, 2014·Nitric Oxide : Biology and Chemistry·Mark A LovichRichard J Gilbert
Jul 3, 2015·Science Translational Medicine·Binglan YuWarren M Zapol
Dec 2, 2015·The Journal of Pharmacology and Experimental Therapeutics·Arpad LuxStefan P Janssens
Oct 26, 2016·Nitric Oxide : Biology and Chemistry·Binglan YuWarren M Zapol
Nov 1, 2016·American Journal of Respiratory and Critical Care Medicine·Lorenzo BerraWarren M Zapol

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Citations

Oct 6, 2018·British Journal of Pharmacology·Binglan YuWarren M Zapol
Jan 22, 2019·Anesthesiology·Warren M Zapol

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