Development of a prediction model for late urinary incontinence, hematuria, pain and voiding frequency among irradiated prostate cancer patients

PloS One
Wouter SchaakeJohannes A Langendijk

Abstract

Incontinence, hematuria, voiding frequency and pain during voiding are possible side effects of radiotherapy among patients treated for prostate cancer. The objective of this study was to develop multivariable NTCP models for these side effects. This prospective cohort study was composed of 243 patients with localized or locally advanced prostate cancer (stage T1-3). Genito-urinary (GU) toxicity was assessed using a standardized follow-up program. The GU toxicity endpoints were scored using the Common Terminology Criteria for Adverse Events version 3.0 (CTCAE 3.0) scoring system. The full bladder and different anatomical subregions within the bladder were delineated. A least absolute shrinkage and selection operator (LASSO) logistic regression analysis was used to analyze dose volume effects on the four individual endpoints. In the univariable analysis, urinary incontinence was significantly associated with dose distributions in the trigone (V55-V75, mean). Hematuria was significantly associated with the bladder wall dose (V40-V75, mean), bladder dose (V70-V75), cardiovascular disease and anticoagulants use. Pain during urinating was associated with the dose to the trigone (V50-V75, mean) and with trans transurethral resection ...Continue Reading

References

Aug 7, 2003·Seminars in Radiation Oncology·Andy TrottiPhilip Rubin
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Stephanie T H PeetersPeter C M Koper
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Patrick W McLaughlinJames Montie
Oct 13, 2007·International Journal of Radiation Oncology, Biology, Physics·Hans Paul van der LaanJohannes A Langendijk
Sep 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claudio FiorinoGiuseppe Sanguineti
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Wilma D HeemsbergenJoos V Lebesque
Sep 3, 2010·American Journal of Epidemiology·Yvonne VergouweEwout W Steyerberg
Jan 22, 2013·International Journal of Radiation Oncology, Biology, Physics·Farshad ForoudiTomas Kron
Jan 31, 2013·BJU International·Michael S LeapmanRichard G Stock
May 15, 2013·International Journal of Radiation Oncology, Biology, Physics·Awad A AhmedMark K Buyyounouski
Aug 13, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wouter SchaakeAlfons C M van den Bergh
Sep 26, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marcel J SteggerdaLuc M F Moonen
Jan 15, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wouter SchaakeJohannes A Langendijk
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Pirus GhadjarAndrew Jackson
Jun 22, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sofie De LangheHubert Thierens
Jan 19, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Federica PaloriniClaudio Fiorino
Mar 20, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Federica PaloriniClaudio Fiorino
Apr 8, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·F PaloriniC Fiorino
May 10, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wouter SchaakeJohannes A Langendijk

❮ Previous
Next ❯

Citations

Jan 28, 2021·Cancers·Daniëlle C VoshartLara Barazzuol
Feb 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sofia SpampinatoUNKNOWN EMBRACE Collaborative Group
Dec 15, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yongqiang LiQing Zhang
Apr 1, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eugenia MylonaRenaud de Crevoisier
Nov 17, 2021·Journal of Applied Clinical Medical Physics·Pei-Chieh YuYu-Lun Tsai

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

R
Elastic
- Net Regularized Generalized Linear Model
Lasso

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.