Development of a prediction model of adverse events after stent placement for esophageal cancer

Gastrointestinal Endoscopy
Lorenzo FuccioGiorgio Battaglia

Abstract

Self-expandable metal stent (SEMS) positioning is the recommended method for palliation of dysphagia from esophageal cancer, although it is not adverse event-free. The present study was aimed at identifying predictors for adverse events and at proposing a statistical model to predict them. We performed a retrospective analysis of a prospectively collected database. All patients who underwent SEMS placement for stricture due to esophageal cancer between 2002 and 2011 in a tertiary-care center were identified. Multivariable regression analysis in the presence of competing risk events was used to identify factors associated with SEMS-related adverse events and to build a prediction model. A total of 267 patients were included. According to the competing risk regression analysis, only 2 variables were significantly associated with the risk of SEMS-related adverse events: prior chemoradiotherapy (CRT), yielding a hazard ratio (HR) of 1.687 (95% confidence interval [CI], 1.076-2.644), and the SEMS length (HR 0.884; 95% CI, 0.798-0.980) for every 10-mm length increase. Based on the estimated probability curves, after 4 months from SEMS placement, the probability of an adverse event in patients who did receive prior CRT was 50.9% compa...Continue Reading

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Citations

Mar 16, 2016·Gastrointestinal Endoscopy·Wouter F W Kappelle, Frank P Vleggaar
Mar 20, 2016·Current Treatment Options in Gastroenterology·Emanuele Dabizzi, Paolo Giorgio Arcidiacono
Aug 2, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lorenzo FuccioAlessio Giuseppe Morganti
Sep 16, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E Rodrigues-PintoG Macedo
Jan 21, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lorenzo FuccioAlessio Giuseppe Morganti
Jan 26, 2017·ACG Case Reports Journal·Giuseppe GrandeRita Conigliaro
Nov 7, 2019·Nanomaterials·Kateřina ŠkrlováDaniela Plachá
Dec 18, 2019·BMC Gastroenterology·Dae Hwan KangHyeong Seok Nam

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