Development of a probucol-releasing antithrombogenic drug eluting stent

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Kumar VedanthamKinam Park

Abstract

The success of drug eluting stents (DESs) has been challenged by the manifestation of late stent thrombosis after DES implantation. The incomplete regeneration of the endothelial layer poststenting triggers adverse signaling processes precipitating in thrombosis. Various approaches have been attempted to prevent thrombosis, including the delivery of biological agents, such as estradiol, that promote endothelialization, and the use of natural polymers as coating materials. The underlying challenge has been the inability to release the biological agent in synchronization with the temporal sequence of vascular wound healing in vivo. The natural healing process of the endothelium after an injury starts after a week and may take up to a month in humans. This article presents a novel DES formulation using a hemocompatible polyurethane (PU) matrix to sustain the release of probucol (PB), an endothelial agonist, by exploiting the greater difference in the solubility parameters of PB and PU. This results in the formation of crystalline PB aggregates retarding drug release from PU. The physicochemical properties of PB in PU were confirmed using differential scanning calorimetry and X-ray diffraction. Drug-polymer compatibility was examin...Continue Reading

References

Feb 1, 1991·Atherosclerosis·A L AkesonR L Jackson
Apr 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G KuR J Dinerstein
Oct 1, 1989·British Journal of Pharmacology·A DaughertyG Schonfeld
Aug 1, 1986·The Journal of Investigative Dermatology·K B SloanF P Flowers
Jan 7, 1998·The New England Journal of Medicine·C R Sirtori, G Franceschini
Jan 15, 2000·Journal of the American College of Cardiology·P H GreweK M Müller
Feb 19, 2000·Current Opinion in Lipidology·R Stocker
Jul 27, 2001·International Journal of Pharmaceutics·K MoserR H Guy
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
May 14, 2003·Circulation·J Eduardo SousaMarco A Costa
Jun 5, 2003·Circulation·Douglas W LosordoLarry J Diaz-Sandoval
Jun 25, 2003·Circulation·Pedro A LemosJ Eduardo Sousa
Sep 25, 2003·Circulation·Andrew FarbRenu Virmani
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Jun 10, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Ilkka UurtoJuha-Pekka Salenius
Jun 20, 2006·Journal of the American College of Cardiology·John CosgraveAntonio Colombo
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Feb 14, 2007·The New England Journal of Medicine·Gregg W StoneMartin B Leon
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Aug 13, 2008·Developmental Cell·Shusheng WangEric N Olson
May 26, 2009·JACC. Cardiovascular Interventions·James R Margolis
Jul 25, 2009·Journal of Interventional Cardiology·Yingying HuangSabareeswaran Arumugam
Mar 2, 2010·Biomaterials·Yingying HuangSudhir Vaishnav
Apr 10, 2010·Journal of the American College of Cardiology·Gareth J PadfieldNicholas L Mills

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Citations

Sep 27, 2013·Expert Opinion on Drug Delivery·Byeongtaek Oh, Chi H Lee
Jul 8, 2015·Therapeutic Delivery·Anne SeidlitzWerner Weitschies
Sep 21, 2013·Molecular Pharmaceutics·Byeongtaek Oh, Chi H Lee

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