Development of a process for the production of the anticancer lead compound pleurotin by fermentation of Hohenbuehelia atrocaerulea

Journal of Industrial Microbiology & Biotechnology
S M ShipleyD J Newman

Abstract

Pleurotin is a naphthoquinone antibiotic originally isolated from Pleurotus griseus. Two pleurotin producing strains of Hohenbuehelia atrocaerulea have been identified, which, on solid substrate fermentation for 2 months yield 1-2 mg/l of the antibiotic. Described here is the lengthy developmental process which resulted in a production protocol being developed which reliably yields pleurotin from liquid fermentation at >300 mg/l. Critical to obtaining this increase in titer was inclusion in the media of an aqueous extract of alder wood.

References

Jun 1, 1947·Proceedings of the National Academy of Sciences of the United States of America·W J RobbinsA Hervey

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Citations

Jan 9, 2009·The New England Journal of Medicine·Michael P W GrocottUNKNOWN Caudwell Xtreme Everest Research Group
Jul 2, 2011·Journal of Applied Physiology·Toni BreskovicZeljko Dujic
Oct 24, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christoph Leithner, Georg Royl
Nov 16, 2013·International Journal of Sports Physiology and Performance·Kai RoeckerStephan Walterspacher
Nov 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christopher K WillieZeljko Dujic
Oct 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Birthe SandargoFrank Surup
Jan 23, 2018·Journal of Natural Products·Birthe SandargoFrank Surup

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