PMID: 9558134Apr 29, 1998Paper

Development of a quantitative vancomycin immunoassay for the Abbott AxSYM analyzer

Therapeutic Drug Monitoring
M AdamczykA G Costantino

Abstract

A novel fluorescence polarization immunoassay for vancomycin on Abbott AxSYM analyzer is described. The immunoassay allows for the accurate quantification of vancomycin in the presence of the crystalline degradation product (CDP). It displays dilution linearity from 1.0 microg/ml to 100.0 microg/ml, coefficients of variation ranging from 2.94% to 4.26%, recovery from 98% to 105%, and a sensitivity of <2.0 microg/ml. The assay demonstrates no cross-reactivity to crystalline degradation product, and to commonly-prescribed and over-the-counter drugs, as well as a minimum interference from endogenous substances.

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Citations

Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Kitahashi, I Furuta
Nov 22, 2013·The Annals of Pharmacotherapy·Tina Harrach DenetclawDouglas Steinke
Jan 12, 2000·The Annals of Pharmacotherapy·P F Smith, G D Morse
Feb 1, 2006·Rapid Communications in Mass Spectrometry : RCM·J DianaE Adams
Jul 29, 2000·Bioorganic & Medicinal Chemistry Letters·M AdamczykZ Yu

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