Development of a realistic human airway model

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Frantisek LizalMiroslav Jicha

Abstract

Numerous models of human lungs with various levels of idealization have been reported in the literature; consequently, results acquired using these models are difficult to compare to in vivo measurements. We have developed a set of model components based on realistic geometries, which permits the analysis of the effects of subsequent model simplification. A realistic digital upper airway geometry except for the lack of an oral cavity has been created which proved suitable both for computational fluid dynamics (CFD) simulations and for the fabrication of physical models. Subsequently, an oral cavity was added to the tracheobronchial geometry. The airway geometry including the oral cavity was adjusted to enable fabrication of a semi-realistic model. Five physical models were created based on these three digital geometries. Two optically transparent models, one with and one without the oral cavity, were constructed for flow velocity measurements, two realistic segmented models, one with and one without the oral cavity, were constructed for particle deposition measurements, and a semi-realistic model with glass cylindrical airways was developed for optical measurements of flow velocity and in situ particle size measurements. One-di...Continue Reading

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Citations

Aug 16, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Frantisek LizalMiroslav Jicha
Feb 1, 2013·Journal of Biomechanical Engineering·Troy MacAveliaRad Zdero
Jul 18, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Emily L KoleweCatherine A Fromen
Oct 5, 2013·Medical Physics·Katsuyuki Taguchi, Jan S Iwanczyk
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Maria NikolaouTheodora Krasia-Christoforou
Jun 22, 2021·Physics of Fluids·Mohammad S IslamSuvash C Saha
Jun 16, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kaveh AhookhoshOtmar Schmid
Jul 7, 2020·Computer Methods and Programs in Biomedicine·W M FaizalRoziana Mohd Razi

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