Development of a resonator with automatic tuning and coupling capability to minimize sample motion noise for in vivo EPR spectroscopy

Journal of Magnetic Resonance
G HeJay L Zweier

Abstract

EPR spectroscopy has been applied to measure free radicals in vivo; however, respiratory, cardiac, and other movements of living animals are a major source of noise and spectral distortion. Sample motions result in changes in resonator frequency, Q, and coupling. These instabilities limit the applications that can be performed and the quality of data that can be obtained. Therefore, it is of great importance to develop resonators with automatic tuning and automatic coupling capability. We report the development of automatic tuning and automatic coupling provisions for a 750-MHz transversely oriented electric field reentrant resonator using two electronically tunable high Q hyperabrupt varactor diodes and feedback loops. In both moving phantoms and living mice, these automatic coupling control and automatic tuning control provisions resulted in an 8- to 10-fold increase in signal-to-noise ratio.

References

Dec 1, 1986·Radiology·J P HornakR G Bryant
May 1, 1995·Journal of Magnetic Resonance. Series B·P KuppusamyJ L Zweier
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P KuppusamyJ L Zweier
Sep 19, 1998·Journal of Magnetic Resonance·W PiaseckiW L Hubbell
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·G HeJ L Zweier
Jan 5, 2000·Journal of Magnetic Resonance·H HirataH M Swartz

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Citations

Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Aug 24, 2005·Antioxidants & Redox Signaling·Viren PatelChandan K Sen
Feb 16, 2011·Journal of Magnetic Resonance·Ayano Enomoto, Hiroshi Hirata
Nov 17, 2007·Journal of Magnetic Resonance·Hiroshi HirataJay L Zweier
Apr 12, 2002·Journal of Magnetic Resonance·Hiroshi HirataYuhei Shimoyama
May 14, 2004·Journal of Magnetic Resonance·Hiroshi HirataYuhei Shimoyama
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guanglong HeJay L Zweier
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hiroshi HirataZhi-Wei Luo
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guanglong HeJay L Zweier
Dec 6, 2005·Molecular and Cellular Biochemistry·Debasis BagchiChandan K Sen
Dec 18, 2008·Physical Chemistry Chemical Physics : PCCP·Giacomo Martini, Laura Ciani
Apr 23, 2002·NMR in Biomedicine

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