Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit.

Basic & Clinical Pharmacology & Toxicology
Fatma M ElgazzarGhada N El-Sarnagawy

Abstract

Early risk stratification of acutely poisoned patients is essential to identify patients at high risk of intensive care unit (ICU) admission. We aimed to develop a prognostic model and risk-stratification nomogram based on the readily accessible clinical and laboratory predictors on admission for the probability of ICU admission in acutely poisoned patients. This retrospective cohort study included adult patients with acute toxic exposure to a drug or a chemical substance. Patients' demographic, toxicologic, clinical and laboratory data were collected. Among the 1260 eligible patients, 180 (14.3%) were admitted to the ICU. We developed a generalized prognostic model for predicting ICU admission in patients with acute poisoning. The predictors included the Glasgow coma scale, oxygen saturation, diastolic blood pressure, respiratory rate and blood bicarbonate concentration. The model displayed excellent discrimination and calibration (optimistic-adjusted area under the curve = 0.924 and optimistic-adjusted Hosmer and Lemeshow test = 0.922, respectively) when internally validated. Additionally, we developed prognostic models that determine ICU admission in patients with specific poisonings. Furthermore, we constructed risk-stratif...Continue Reading

References

Aug 4, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Alex Z FuMichael W Kattan
Nov 1, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Vincent LiuGabriel J Escobar
Oct 15, 2013·Asian Journal of Andrology·Shu-Chun KuoChien-Cheng Huang
Jun 27, 2014·American Journal of Epidemiology·Gordon C S SmithIan R White
Jan 24, 2015·QJM : Monthly Journal of the Association of Physicians·R ConwayB Silke
Jan 27, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Zihni SulajGentian Vyshka
Apr 9, 2015·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Maria BjørnChristian B Mogensen
Aug 13, 2015·BMJ : British Medical Journal·Menelaos PavlouRumana Z Omar
Sep 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·In O SunKwang Young Lee
Feb 10, 2016·Nigerian Journal of Clinical Practice·S YaylaciA Tamer
May 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Kyunghwa HanByoung Wook Choi
Jun 25, 2016·Human & Experimental Toxicology·Ghada N El-Sarnagawy, Amal Saf Hafez
Sep 21, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Raya BrandenburgDylan W de Lange
Nov 17, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Regina BöllChristian Rabe
Dec 23, 2017·Computational and Mathematical Methods in Medicine·Seán CournaneBernard Silke
Jan 24, 2018·Journal of Intensive Care Medicine·Shannon M FernandoKwadwo Kyeremanteng
Mar 13, 2018·Basic & Clinical Pharmacology & Toxicology·Esmaeil FarzanehOmid Mehrpour
Nov 9, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Lalit Kumar RajbanshiRakesh Mandal
Feb 23, 2019·Science·Ravi B ParikhAmol S Navathe

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