Development of a Risk Score Based on Aortic Calcification to Predict 1-Year Mortality After Transcatheter Aortic Valve Replacement

JACC. Cardiovascular Imaging
Pierre LantelmeBrahim Harbaoui

Abstract

The aim of this study was to develop a new scoring system based on thoracic aortic calcification (TAC) to predict 1-year cardiovascular and all-cause mortality. A calcified aorta is often associated with poor prognosis after transcatheter aortic valve replacement (TAVR). A risk score encompassing aortic calcification may be valuable in identifying poor TAVR responders. The C4CAPRI (4 Cities for Assessing CAlcification PRognostic Impact) multicenter study included a training cohort (1,425 patients treated using TAVR between 2010 and 2014) and a contemporary test cohort (311 patients treated in 2015). TAC was measured by computed tomography pre-TAVR. CAPRI risk scores were based on the linear predictors of Cox models including TAC in addition to comorbidities and demographic, atherosclerotic disease and cardiac function factors. CAPRI scores were constructed and tested in 2 independent cohorts. Cardiovascular and all-cause mortality at 1 year was 13.0% and 17.9%, respectively, in the training cohort and 8.2% and 11.8% in the test cohort. The inclusion of TAC in the model improved prediction: 1-cm3 increase in TAC was associated with a 6% increase in cardiovascular mortality and a 4% increase in all-cause mortality. The predicted ...Continue Reading

Citations

May 22, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R R LopesH A Marquering
Feb 10, 2021·Expert Review of Cardiovascular Therapy·Tanush GuptaNeal S Kleiman
Aug 29, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Pradyumna AgasthiReza Arsanjani
Mar 12, 2021·European Heart Journal Cardiovascular Imaging·Brahim HarbaouiPierre Lantelme
Apr 23, 2020·The American Journal of Cardiology·Clément BèclePierre Lantelme
Jul 6, 2020·The American Journal of Cardiology·Pierre LantelmeLaurent Fauchier
Oct 28, 2019·Annales de cardiologie et d'angéiologie·P Lantelme, B Harbaoui
Aug 29, 2019·International Journal of Cardiology·Brahim HarbaouiPierre Lantelme
Nov 18, 2020·Annals of Surgery·Francesco Pollari, Theodor Fischlein

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