Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

Pharmaceutics
Daniélle van StadenJoe Viljoen

Abstract

A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and water-titration experiments identified spontaneous emulsification capacity of different excipient combinations and clofazimine. After identifying self-emulsification regions, check-point formulations were selected within the self-emulsification region by considering characteristics required to achieve optimized topical drug delivery. Check-point formulations, able to withstand phase separation after 24 h at an ambient temperature, were subjected to characterization studies. Experiments involved droplet size evaluation; size distribution; zeta-potential; self-emulsification time and efficacy; viscosity and pH measurement; cloud point assessment; and thermodynamic stability studies. SEDDSs with favorable properties, i.e., topical drug delivery, were subjected to dermal diffusion studies. Successful in vitro topical clofazimine delivery was observed. Olive oil facilitated the highest topical delivery of clofazimine probably due to increased oleic acid levels that enhanced stratum corneum lipid disruption, followed b...Continue Reading

References

Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·C JagannathP R Gangadharam
Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C W Pouton
Jan 25, 2003·The Journal of Investigative Dermatology·Ronald R WarnerYing L Boissy
Jul 4, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Colin W Pouton
Dec 11, 2007·Advanced Drug Delivery Reviews·Colin W Pouton, Christopher J H Porter
Aug 8, 2008·Drug Delivery·Min-Jung KimHan-Gon Choi
Jul 6, 2010·International Journal of Pharmaceutics·Ghada M El ZaafaranyNahed D Mortada
Feb 10, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gul ShahnazAndreas Bernkop-Schnürch
Oct 25, 2011·The Journal of Antimicrobial Chemotherapy·Moloko C CholoRonald Anderson
Oct 12, 2012·The Journal of Antimicrobial Chemotherapy·Teesta DeyNathan Ford
Mar 7, 2013·International Journal of Pharmaceutics·Majella E Lane
Aug 13, 2013·ISRN Pharmaceutics·Rahul Rama HegdeAmitava Ghosh
Jan 10, 2014·Drug Delivery·Saeed GhanbarzadehSanam Arami
Jun 19, 2014·Critical Reviews in Therapeutic Drug Carrier Systems·Bhupinder SinghOm Parkash Katare
Jan 31, 2015·Advances in Colloid and Interface Science·A PerazzoS Guido
Jul 15, 2015·Drug Development and Industrial Pharmacy·Joe M ViljoenJeanetta du Plessis
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Czajkowska-KośnikKatarzyna Winnicka
Dec 1, 2015·Tuberculosis·Lindi van ZylJoe Viljoen
Jan 23, 2016·Drug Design, Development and Therapy·Gehan F BalataMohammed As Abourehab
Jan 29, 2016·Scientific Reports·Maja-Lisa ClausenTove Agner
Feb 9, 2016·Journal of Pharmaceutical Sciences·Lindi van ZylJoe Viljoen
Jun 5, 2016·International Journal of Pharmaceutics·Jonathan Hadgraft, Majella E Lane
Jan 1, 2014·International Scholarly Research Notices·Samatha AkulaSrinivas Reddy Devireddy
Sep 7, 2016·Mathematical Biosciences·J G JonesM B Delgado-Charro
Sep 7, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anita UmerskaPatrick Saulnier
Nov 1, 2016·The Journal of Antimicrobial Chemotherapy·Moloko C CholoRonald Anderson
Mar 23, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S KöllnerA Bernkop-Schnürch
Apr 16, 2017·Journal of Colloid and Interface Science·Ioanna ZafeiriFotis Spyropoulos
May 21, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Randa S H MansourIbraheem Yousef
Jun 8, 2017·Drug Development and Industrial Pharmacy·Ožbej ZupančičAndreas Bernkop-Schnürch
Jul 15, 2017·American Journal of Clinical Dermatology·Alexandra R VaughnVivian Y Shi
Sep 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vytis ČižinauskasVitalis Briedis
Dec 5, 2017·International Journal of Pharmaceutics·Tina KaussKaren Gaudin
Dec 25, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jon R HeylingsRebecca Burton
Mar 5, 2018·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Martin RaoMarkus Maeurer
May 29, 2018·Food Research International·Nicola CiceroGiacomo Dugo
Jun 5, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Magnus LundborgLars Norlén

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Citations

Jul 3, 2021·Pharmaceutics·Sreeharsha NagarajaSwati Pund
Jul 18, 2021·Journal of Pharmaceutical and Biomedical Analysis·Xun ZhaoYaozuo Yuan

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Methods Mentioned

BETA
RSA
dynamic light scattering

Software Mentioned

Triplot

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