PMID: 7581290May 1, 1995Paper

Development of a simple and selective separation of 67Cu from irradiated zinc for use in antibody labelling: a comparison of methods

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
R SchwarzbachP A Schubiger

Abstract

A procedure for the production and separation of Cu isotopes from irradiated Zn was developed. Following a comparison of methods based on extraction, electrolysis and ion-exchange chromatography, a technique for the separation of Cu employing three ion-exchange matrices was developed which was simple, reproducible and hot cell-compatible. The specific activity of the final product was 37 MBq 67Cu/microgram Cu at EOB. The level of impurities was so low that no interference with antibody labelling was observed.

References

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Citations

May 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Karl-Dimiter BissigMarc Solioz
Nov 1, 1996·Nuclear Medicine and Biology·P J BlowerJ Zweit
Oct 2, 2012·PloS One·Hanwen ZhangHelmut R Maecke
Mar 24, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Amir R JalilianMehdi Akhlaghi
Jan 1, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Valeriia N StarovoitovaDouglas P Wells
Feb 14, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S ThiemeJ Steinbach
Nov 4, 2004·Journal of Inorganic Biochemistry·Suzanne V Smith
Oct 19, 2006·Nuclear Medicine and Biology·Xianfeng FanJonathan P K Seville
Aug 9, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Nicholas A SmithDavid A Ehst
Oct 22, 2014·Scientific Reports·Tara MastrenSuzanne E Lapi
Dec 27, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Pejman RowshanfarzadMohsen Kamalidehghan
Nov 8, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Syed M Qaim, Ingo Spahn
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karin KnoglerIlse Novak-Hofer
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jürgen GrünbergP August Schubiger
Jan 27, 2021·Physics in Medicine and Biology·Michael J MerrickStephen A Graves
Apr 30, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Samer K I AliA Sulieman
Oct 10, 2018·Chemical Reviews·Eszter Boros, Alan B Packard

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