Development of a single-shot subunit vaccine for HIV-1. 3. Effect of adjuvant and immunization schedule on the duration of the humoral immune response to recombinant MN gp120

Journal of Pharmaceutical Sciences
J L ClelandM F Powell

Abstract

HIV-1 prophylaxis may require "sterilizing immunity" (i.e., the prevention of infection), and this is likely to demand a vaccine that gives high, long-lasting antibody titers. Although it is known that vaccine adjuvants and immunization schedule affect the magnitude of the immune response, there are few reports on antibody decay rates and persistence. Guinea pigs were immunized with recombinant gp120 using different adjuvants and immunization schedules, and the anti-gp120 and HIV-1 neutralization titers were determined over time following the last booster immunization. As observed previously in the literature, a longer time between boosting gave higher titers, with a slight increase in the decay half-life as the booster was spaced farther out from the primary immunization. The decay rate of the antibody titers showed surprisingly little effect of adjuvant, except for sustained-release polymer-based formulations. Adjuvants that gave high titers initially after boosting showed the greatest persistence of antibody titers (persistence defined as the residual titers at long times). These data show that high, long-lasting titers may be achieved by using sustained-release formulations, and these are likely the prime vaccine candidates...Continue Reading

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·R LangerJ Hanes
Jun 6, 2000·Advanced Drug Delivery Reviews·N J Medlicott, I G Tucker
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P JohansenB Gander
Mar 29, 2014·Current Opinion in HIV and AIDS·M Anthony Moody
Jul 23, 2004·Expert Opinion on Biological Therapy·Jeffrey B Ulmer
Apr 23, 2004·Expert Opinion on Biological Therapy·Manmohan SinghDerek T O'Hagan
Apr 18, 2003·AIDS·Derek T O'Hagan, Ed Lavelle
Nov 20, 2004·Immunology and Cell Biology·Michael VajdyManmohan Singh
Nov 26, 2010·Expert Review of Vaccines·Antu K Dey, Indresh K Srivastava
Dec 18, 2010·Expert Review of Vaccines·George MutwiriAndrew Potter

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