Development of a standardized method for contouring the lumbosacral plexus: a preliminary dosimetric analysis of this organ at risk among 15 patients treated with intensity-modulated radiotherapy for lower gastrointestinal cancers and the incidence of radiation-induced lumbosacral plexopathy

International Journal of Radiation Oncology, Biology, Physics
Sun K YiLy Do

Abstract

To generate a reproducible step-wise guideline for the delineation of the lumbosacral plexus (LSP) on axial computed tomography (CT) planning images and to provide a preliminary dosimetric analysis on 15 representative patients with rectal or anal cancers treated with an intensity-modulated radiotherapy (IMRT) technique. A standardized method for contouring the LSP on axial CT images was devised. The LSP was referenced to identifiable anatomic structures from the L4-5 interspace to the level of the sciatic nerve. It was then contoured retrospectively on 15 patients treated with IMRT for rectal or anal cancer. No dose limitations were placed on this organ at risk during initial treatment planning. Dosimetric parameters were evaluated. The incidence of radiation-induced lumbosacral plexopathy (RILSP) was calculated. Total prescribed dose to 95% of the planned target volume ranged from 50.4 to 59.4 Gy (median 54 Gy). The mean (± standard deviation [SD]) LSP volume for the 15 patients was 100 ± 22 cm(3) (range, 71-138 cm(3)). The mean maximal dose to the LSP was 52.6 ± 3.9 Gy (range, 44.5-58.6 Gy). The mean irradiated volumes of the LSP were V40Gy = 58% ± 19%, V50Gy = 22% ± 23%, and V55Gy = 0.5% ± 0.9%. One patient (7%) was found t...Continue Reading

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Citations

Nov 27, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C PisaniM Krengli
Jun 17, 2016·Radiation Oncology Journal·Malcolm D MattesChristopher A Barker
Mar 15, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dominique RashJyoti Mayadev
Jun 22, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Finbar SlevinAnn M Henry
Oct 22, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·M C TjongD B Shultz

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