Development of a statistical approach to classifying treatment response in individual children with ADHD

Human Psychopharmacology
Catherine M MollicaAlasdair Vance

Abstract

The use of cognitive tests as measures of treatment response in individual children with ADHD has not been adequately evaluated or commonly applied by clinicians. This is most likely due to a lack of suitable assessment tasks as well as clinicians' limited awareness of the appropriate statistical techniques for analysing cognitive change in individuals. This study investigated the application of statistical decision rules to the cognitive and behavioural measures of individual children with ADHD in order to classify a significant, positive response to medication. The previously reported data of 14 children with ADHD (combined type; ADHD-CT) were re-analysed to investigate changes in function following a low- and high-dose of stimulant medication (2.5 mg and 7.5 mg dexamphetamine, respectively). The performances of 14 age-, gender- and IQ-matched controls was also analysed to provide an estimate of the false-positive classification rate. Overall, the decision rule yielded a high sensitivity and high specificity to treatment response. In the high-dose condition, 71% of children with ADHD demonstrated improvements in both cognitive and behavioural function. This study demonstrates an evidence-based approach to evaluating concurren...Continue Reading

Citations

May 7, 2009·Journal of Clinical Psychology in Medical Settings·Amori Yee MikamiRoger Burket
May 9, 2009·Neuropsychology Review·Lucette A Cysique, Bruce J Brew
Apr 20, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Matthew S LewisDavid A Scott
May 2, 2008·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Robert H PietrzakPeter J Snyder
Jul 19, 2012·Cognitive Neuropsychiatry·Karina L AllenJonathan K Foster
Apr 28, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Paul MaruffRobert H Pietrzak
Dec 15, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Anton D Hinton-Bayre
May 25, 2006·British Journal of Sports Medicine·P MaruffD Darby
Mar 20, 2010·American Journal of Respiratory and Critical Care Medicine·James C JacksonE Wesley Ely
Nov 8, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jin-Shei LaiStewart Goldman
Jan 1, 2015·Applied Neuropsychology. Child·Jacqueline WilliamsVicki Anderson
Jan 13, 2016·Journal of Autism and Developmental Disorders·Emeline CrutcherChristian P Schaaf
Mar 13, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David G DarbyPaul Maruff
Oct 1, 2005·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter J SnyderPaul Maruff
Jun 16, 2015·Frontiers in Psychology·Jason A CromerPaul Maruff
Jul 23, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Catherine M MollicaAlasdair Vance
Apr 14, 2007·Stroke; a Journal of Cerebral Circulation·Satwant K SamraUNKNOWN CFAAST Investigators
Jan 28, 2006·Hormone Research·Paul Maruff, Marina Falleti
Jan 6, 2012·Journal of Developmental and Behavioral Pediatrics : JDBP·Tanja V E KralMyles S Faith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.