Development of a thermosensitive protein conjugated nanogel for enhanced radio-chemotherapy of cancer

Nanoscale
Debabrata MaitiKai Yang

Abstract

Although chemo-radiotherapy has been widely applied in clinics for cancer treatment, current strategies still face many challenges including serious side-effects and drug resistance. Herein, we develop a chemically cross-linked poly-N,N'-dimethyl aminoethyl methacrylate (PDMAEMA) smart nanogel as an excellent thermosensitive nanocarrier to load both an anticancer drug, doxorubicin (DOX) and a radioisotope, 131I-labeled albumin, for enhanced chemo-radioisotope therapy. Such a PDMAEMA nanogel in the solution form at room temperature can be easily injected into a tumor, in which it would be transformed into a gel at body temperature. Sustained drug release occurs in the tumor owing to the pH sensitive switching activity of the nanogel. In addition, the in situ thermogelling behavior of PDMAEMA leads to the long-term retention of 131I-labeled albumin within the tumor. In vivo chemo-radiotherapy is then conducted, achieving excellent therapeutic efficacy due to the sustained drug release and 131I retention for a long time in the cancer lesions. Our newly developed strategy of using a thermosensitive polymer for enhancing chemo-radiotherapy may be considered as a promising platform for combined cancer therapy without inducing obvious...Continue Reading

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Citations

Jan 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao TaoDong-An Wang
Nov 16, 2018·Nanomaterials·Paola Sánchez-MorenoHouria Boulaiz
Dec 12, 2020·Biomaterials Science·Zhen LiJun Wu
Jan 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rui-Zhi TangXi-Qiu Liu
Apr 24, 2021·Drug Discovery Today·Ana C MarquesMaria H Amaral
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yibin YuMei Tian
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Sophie NieuwenhuisPeter Müller-Buschbaum
Mar 13, 2019·ACS Applied Materials & Interfaces·Allison N DuRossConroy Sun
Jul 12, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Xianyu SongHonglai Liu

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Methods Mentioned

BETA
fluorescence imaging
1
scanning
transmission electron microscopy

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