Development of a touch-screen-based paradigm for assessing working memory in the mouse

Experimental Neurobiology
Chuljung KwakBong-Kiun Kaang

Abstract

Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse.

References

Oct 3, 2003·Nature Reviews. Neuroscience·Alan Baddeley
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Paul A Dudchenko
Mar 10, 2010·Behavioural Processes·Kazuhiro GotoShigeru Watanabe
Sep 21, 2013·Nature Protocols·Alexa E HornerTimothy J Bussey
Sep 21, 2013·Nature Protocols·Adam C MarTimothy J Bussey
Aug 28, 2014·Molecular Brain·Sheng-Tao YangBao-Ming Li

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Citations

Dec 25, 2015·Behavioural Brain Research·Chuljung KwakBong-Kiun Kaang

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