Development of a travelers' diarrhea vaccine for the military: how much is an ounce of prevention really worth?

Vaccine
Mark S RiddleTomoko I Hooper

Abstract

Infectious diarrhea is one of the many threats to the deployed military, and given limited resources, a decision to pursue a vaccine acquisition strategy should be based on best evidence that weighs costs and benefits compared to alternatives. An economic model was developed to estimate the marginal cost to avert a duty day lost due to diarrhea for a vaccine acquisition strategy compared to current clinical management, for both multiplex and pathogen-specific vaccines. Vaccines against Campylobacter and enterotoxigenic Escherichia coli appeared to be more favorable than a Shigella vaccine. This model provides an evidence-based decision tool to support prioritization in vaccine development.

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Nov 30, 2019·Military Medicine·Tahaniyat LalaniDavid R Tribble

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