PMID: 20631434Jul 16, 2010Paper

Development of a UPLC-ESI-MS/MS assay for 20(S)-protopanaxadiol and pharmacokinetic application of its two formulations in rats

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Meihua HanXiangtao Wang

Abstract

An ultra-performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed to investigate 20(S)-protopanaxadiol (PPD) pharmacokinetics in rats. Rat plasma samples were treated using a solid-phase extraction with satisfactory recovery (> 81%). The method showed an excellent sensitivity that the limit of detection (LOD) and the lower limit of quantitation (LLOQ) of PPD were 0.5 and 2 ng/mL, respectively. The method was applied to the evaluation of pharmacokinetics from two types of PPD formulations. The PPD emulsion showed more rapid and efficient drug absorption, and higher and more persistent plateau concentration of PPD in plasma than PPD oil solution. PPD emulsion was demonstrated to be a promising dosage form. In spite of lower plateau plasma drug concentration, PPD oil solution was characterized by the easiness in preparation and the persistent, durative plateau plasma concentration of PPD, there is room to further improve its bioavailability.

References

Jul 18, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mona Abdel TawabManfred Schubert-Zsilavecz
Jul 15, 2004·Journal of Biochemical and Molecular Toxicology·David G Popovich, David D Kitts
Mar 1, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hai-Tang XieWei Wang
May 17, 2006·Basic & Clinical Pharmacology & Toxicology·Gang LiZiren Wang
May 30, 2006·Biochemical and Biophysical Research Communications·Jing JinTai-Ping Fan
Nov 22, 2008·Journal of Pharmaceutical and Biomedical Analysis·Hong-Can RenFang Zhou

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Citations

Feb 22, 2012·Drug Development and Industrial Pharmacy·Yanfei LuoXing Tang
Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yiqiong PuTong Zhang
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qi ZhangZhenzhen Cai

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